Appeal and Sensory Characteristics of Oral Nicotine Products in Young Adults Who Vape E-Cigarettes.

IF 3 2区医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Nicotine & Tobacco Research Pub Date : 2024-11-28 DOI:10.1093/ntr/ntae281

Natalia Peraza, Dae Hee Han, Reid C Whaley, Erin A Vogel, John R Monterosso, Maria J Gonzalez Anaya, Devaki J Patel, Nikki S Jafarzadeh, Kurt Hong, Tyler B Mason, Alayna P Tackett, Adam M Leventhal

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Abstract

Introduction: This study applied a novel tobacco regulatory science paradigm to characterize inter-product variation in the appeal and sensory features of emerging commercial and therapeutic oral nicotine products (ONPs) among young adults that vape e-cigarettes.

Methods: Twenty-three young adults without ONP experience who use e-cigarettes completed a single-blind, single-visit remote lab study. Participants rated appeal and sensory characteristics during 5-minute standardized self-administrations of 8 ONPs (4 fruit, 4 mint) from various brands (Lucy, Rouge, Solace, Nicorette, On!, Velo). Participants were randomized between-subjects to ONP type (pouches or gum).

Results: Gum ONPs were rated sweeter (B = 19.5, 95% CI = 4.3, 34.7), stronger in flavor (B = 25.6, 95% CI = 12.2, 39.0), and lower in tingling sensation (B = -14.0, 95% CI = -27.8, -0.2) than pouches. Fruit-flavored ONPs were sweeter (B = 12.9, 95% CI = 6.1, 19.7) and caused less burning (B = -12.0, 95% CI = -19.5, -4.5) than mint. Product type x flavor interactions found that gum vs. pouch enhanced sweetness and flavor strength more for fruit than mint, while pouch vs. gum increased burning and harshness more for mint. Nicorette White Ice was most appealing, while Rogue Fruit and Nicorette Mint were less so. Appeal correlated with most types of sensory experiences (rs = -.33-.54), except for tingling and burning.

Conclusions: Nicotine gums may offer a more pleasant sensory experience than pouches for young adults who use e-cigarettes, with variation across brand/flavor variants.

Implications: Results indicate that gum ONPs and fruit flavors may offer greater appeal and a more pleasant sensory experience than pouch ONPs and mint flavors for young adults who use e-cigarettes and are ONP-naïve, with heterogeneity in user experience across some brand/flavor variants. This study also introduces a method for assessing the appeal and sensory features of ONPs, which can inform regulatory efforts and strategies to reduce nicotine dependence among young adults who use e-cigarettes.

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口服尼古丁产品对吸食电子烟的年轻人的吸引力和感官特征。

导言：本研究采用一种新颖的烟草监管科学范式来描述吸食电子烟的年轻人对新兴商业和治疗性口服尼古丁产品（ONPs）的吸引力和感官特征的产品间差异：23名没有使用过口服尼古丁产品的年轻人完成了一项单盲、单次访问的远程实验室研究。参与者在 5 分钟内对不同品牌（Lucy、Rouge、Solace、Nicorette、On!受试者之间随机分配 ONP 类型（小袋或口香糖）：口香糖型 ONP 的甜度（B = 19.5，95% CI = 4.3，34.7）、味道（B = 25.6，95% CI = 12.2，39.0）和刺痛感（B = -14.0，95% CI = -27.8，-0.2）均高于小袋型 ONP。与薄荷糖相比，水果味 ONP 更甜（B = 12.9，95% CI = 6.1，19.7），引起的灼烧感更小（B = -12.0，95% CI = -19.5，-4.5）。产品类型 x 口味的交互作用发现，口香糖与小袋装相比，水果味比薄荷味更能增强甜味和口味强度，而小袋装与口香糖相比，薄荷味更能增强灼烧感和刺激感。Nicorette White Ice 的吸引力最大，而 Rogue Fruit 和 Nicorette Mint 的吸引力较小。除刺痛感和灼烧感外，吸引力与大多数类型的感官体验相关（rs = -.33-.54）：结论：对于使用电子烟的年轻人来说，尼古丁口香糖可能会比烟袋提供更愉悦的感官体验，但不同品牌/不同口味的尼古丁口香糖会有差异：研究结果表明，对于使用电子烟且对电子烟一无所知的年轻人来说，口香糖和水果口味的电子烟可能比小袋装的电子烟和薄荷口味的电子烟更有吸引力，能给他们带来更愉悦的感官体验，但在某些品牌/口味的变体中，用户体验存在差异。这项研究还介绍了一种评估ONP吸引力和感官特征的方法，可为监管工作和减少使用电子烟的年轻人尼古丁依赖性的策略提供参考。

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来源期刊

Nicotine & Tobacco Research 医学-公共卫生、环境卫生与职业卫生

CiteScore

8.10

自引率

10.60%

发文量

268

审稿时长

3-8 weeks

期刊介绍： Nicotine & Tobacco Research is one of the world''s few peer-reviewed journals devoted exclusively to the study of nicotine and tobacco. It aims to provide a forum for empirical findings, critical reviews, and conceptual papers on the many aspects of nicotine and tobacco, including research from the biobehavioral, neurobiological, molecular biologic, epidemiological, prevention, and treatment arenas. Along with manuscripts from each of the areas mentioned above, the editors encourage submissions that are integrative in nature and that cross traditional disciplinary boundaries. The journal is sponsored by the Society for Research on Nicotine and Tobacco (SRNT). It publishes twelve times a year.