Optimal control of vaccination for an epidemic model with standard incidence rate

Abstract

A critical challenge for diseases spread is the development of effective prevention and control measures while minimizing costs, representing the foremost priority. Unfortunately, research in this crucial area remains inadequately explored. Consequently, this paper addresses the issue by leveraging an SI reaction–diffusion epidemic model incorporating a logistic birth rate and standard incidence rate. Employing vaccination as a control variable and integrating sparse optimal control theory, the study elucidates the achievement of epidemic prevention and control through the optimization of resource allocation, emphasizing a perspective rooted in pattern structure transformation. On the one hand, we theoretically prove the existence of the optimal solutions, first-order necessary optimality conditions, and the sparsity properties. On the other hand, we use numerical simulations to verify the rationality of the control method and the effectiveness of the control strategy from three aspects of control effect, control error and control cost. In addition, tailored targeting options are proposed based on the economic status of each region, specifying the required inoculum amount for each moment. Ultimately, the study demonstrates the effectiveness of input vaccination in controlling epidemics in a majority of areas. In summary, this work offers crucial insights into the prevention and control of a non-quasimonotonic reaction–diffusion epidemic model.