On the origin of mitosis-derived human embryo aneuploidy

IF 15.7 1区 综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES Nature Communications Pub Date : 2024-11-29 DOI:10.1038/s41467-024-54953-0
Jiyeon Leem, Madison Gowett, Sarah Bolarinwa, Binyam Mogessie
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Abstract

Chromosome segregation errors are common in the early stages of human embryonic development. By examining the first mitotic divisions of human embryos using live cell imaging, three recent studies identify spindle architecture and positioning features that could provide insights into why early embryos are predisposed to chromosomal abnormalities.

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关于有丝分裂衍生的人胚胎非整倍体的起源
染色体分离错误在人类胚胎发育的早期阶段是常见的。通过使用活细胞成像检查人类胚胎的第一次有丝分裂,最近的三项研究确定了纺锤体结构和定位特征,这些特征可以为早期胚胎易患染色体异常的原因提供见解。
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来源期刊
Nature Communications
Nature Communications Biological Science Disciplines-
CiteScore
24.90
自引率
2.40%
发文量
6928
审稿时长
3.7 months
期刊介绍: Nature Communications, an open-access journal, publishes high-quality research spanning all areas of the natural sciences. Papers featured in the journal showcase significant advances relevant to specialists in each respective field. With a 2-year impact factor of 16.6 (2022) and a median time of 8 days from submission to the first editorial decision, Nature Communications is committed to rapid dissemination of research findings. As a multidisciplinary journal, it welcomes contributions from biological, health, physical, chemical, Earth, social, mathematical, applied, and engineering sciences, aiming to highlight important breakthroughs within each domain.
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