Sex differences in the trajectories of plasma biomarkers, brain atrophy, and cognitive decline relative to amyloid onset

IF 11.1 1区医学 Q1 CLINICAL NEUROLOGY Alzheimer's & Dementia Pub Date : 2024-11-28 DOI:10.1002/alz.14405

Cassandra M. Joynes, Murat Bilgel, Yang An, Abhay R. Moghekar, Nicholas J. Ashton, Przemysław R. Kac, Thomas K. Karikari, Kaj Blennow, Henrik Zetterberg, Madhav Thambisetty, Luigi Ferrucci, Susan M. Resnick, Keenan A. Walker

{"title":"Sex differences in the trajectories of plasma biomarkers, brain atrophy, and cognitive decline relative to amyloid onset","authors":"Cassandra M. Joynes, Murat Bilgel, Yang An, Abhay R. Moghekar, Nicholas J. Ashton, Przemysław R. Kac, Thomas K. Karikari, Kaj Blennow, Henrik Zetterberg, Madhav Thambisetty, Luigi Ferrucci, Susan M. Resnick, Keenan A. Walker","doi":"10.1002/alz.14405","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> INTRODUCTION</h3>\n \n <p>The factors that influence the progression of Alzheimer's disease (AD) after individuals become amyloid-positive are poorly understood. This study examines how sex influences the longitudinal trajectories of plasma AD and neurodegenerative biomarkers in the years following a person's estimated onset of amyloid-β.</p>\n </section>\n \n <section>\n \n <h3> METHODS</h3>\n \n <p>Linear mixed-effects modeling investigated overall and sex-specific longitudinal trajectories of plasma biomarkers, brain volumes, and cognition relative to the estimated age of amyloid onset in a cohort of 78 amyloid-positive Baltimore Longitudinal Study of Aging (BLSA) participants (<i>n</i> = 45 male; follow-up time: 6.8 years [SD 3.31]). Amyloid status was ascertained with <sup>11</sup>C-Pittsburgh compound B (PiB) PET imaging.</p>\n </section>\n \n <section>\n \n <h3> RESULTS</h3>\n \n <p>After amyloid onset, men displayed steeper increases in pTau181, pTau231, and neurofilament light (NfL) compared to women. In this same period, men demonstrated steeper declines in brain volume and cognitive performance.</p>\n </section>\n \n <section>\n \n <h3> DISCUSSION</h3>\n \n <p>These findings suggest that sex influences the trajectory of AD pathology, neuronal injury, and symptom progression after individuals become amyloid-positive.</p>\n </section>\n \n <section>\n \n <h3> Highlights</h3>\n \n <div>\n <ul>\n \n <li>Steeper rates of increase in pTau and GFAP among amyloid-positive individuals.</li>\n \n <li>After amyloid onset, steeper increases in pTau and NfL concentrations in men than in women.</li>\n \n <li>Steeper declines in brain volume and cognition in men corroborate biomarker results.</li>\n </ul>\n </div>\n </section>\n </div>","PeriodicalId":7471,"journal":{"name":"Alzheimer's & Dementia","volume":"21 1","pages":""},"PeriodicalIF":11.1000,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/alz.14405","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Alzheimer's & Dementia","FirstCategoryId":"3","ListUrlMain":"https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/alz.14405","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

INTRODUCTION

The factors that influence the progression of Alzheimer's disease (AD) after individuals become amyloid-positive are poorly understood. This study examines how sex influences the longitudinal trajectories of plasma AD and neurodegenerative biomarkers in the years following a person's estimated onset of amyloid-β.

METHODS

Linear mixed-effects modeling investigated overall and sex-specific longitudinal trajectories of plasma biomarkers, brain volumes, and cognition relative to the estimated age of amyloid onset in a cohort of 78 amyloid-positive Baltimore Longitudinal Study of Aging (BLSA) participants (n = 45 male; follow-up time: 6.8 years [SD 3.31]). Amyloid status was ascertained with ¹¹C-Pittsburgh compound B (PiB) PET imaging.

RESULTS

After amyloid onset, men displayed steeper increases in pTau181, pTau231, and neurofilament light (NfL) compared to women. In this same period, men demonstrated steeper declines in brain volume and cognitive performance.

DISCUSSION

These findings suggest that sex influences the trajectory of AD pathology, neuronal injury, and symptom progression after individuals become amyloid-positive.

Highlights

Steeper rates of increase in pTau and GFAP among amyloid-positive individuals.
After amyloid onset, steeper increases in pTau and NfL concentrations in men than in women.
Steeper declines in brain volume and cognition in men corroborate biomarker results.

Abstract Image

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

与淀粉样蛋白发病相关的血浆生物标志物、脑萎缩和认知能力下降轨迹的性别差异

个体淀粉样蛋白阳性后影响阿尔茨海默病（AD）进展的因素尚不清楚。这项研究探讨了性别如何影响血浆AD和神经退行性生物标志物的纵向轨迹，在一个人估计淀粉样蛋白-β发病后的几年中。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Alzheimer's & Dementia 医学-临床神经学

CiteScore

14.50

自引率

5.00%

发文量

299

审稿时长

3 months

期刊介绍： Alzheimer's & Dementia is a peer-reviewed journal that aims to bridge knowledge gaps in dementia research by covering the entire spectrum, from basic science to clinical trials to social and behavioral investigations. It provides a platform for rapid communication of new findings and ideas, optimal translation of research into practical applications, increasing knowledge across diverse disciplines for early detection, diagnosis, and intervention, and identifying promising new research directions. In July 2008, Alzheimer's & Dementia was accepted for indexing by MEDLINE, recognizing its scientific merit and contribution to Alzheimer's research.