Catheter-related bloodstream infection by a newly proposed “Mycobacterium toneyamachuris” in a boy with B-cell precursor acute lymphoblastic leukemia

IF 2.1 4区 医学 Q3 INFECTIOUS DISEASES Diagnostic microbiology and infectious disease Pub Date : 2024-11-23 DOI:10.1016/j.diagmicrobio.2024.116626
Haruki Naruse , Noriyuki Watanabe , Atsuhiko Ohta , Yuuki Shimizu , Takashi Fukushima , Atsuko Watanabe , Tomohei Nakao , Yoshitada Taji , Yuki Matsumoto , Shota Nakamura , Yuriko Igarashi , Akiko Takaki , Satoshi Mitarai , Kotaro Mitsutake , Ryuhei Tanaka , Yasuhiro Ebihara
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Abstract

This report describes a 6-year-old boy who developed non-tuberculosis mycobacteria (NTM) catheter-related bloodstream infection (CRBSI) during treatment for B-cell precursor acute lymphoblastic leukemia. A Hickman catheter was inserted before starting treatment. He developed a fever during chemotherapy, and blood culture was drawn from the catheter. Blurred Gram-positive bacilli were found in Gram stain, looked positive in Ziehl–Neelsen stain, and were identified by matrix-assisted laser desorption/ionization-time of flight mass spectrometry as Mycobacterium mucogenicum phocaicum group. The administration of clarithromycin and amikacin was started and the Hickman catheter was removed. We performed genomic sequencing to obtain accurate identification, demonstrating that this microorganism was identified as “M. toneyamachuris” calculated by the average nucleotide identity index. Finally, a clinical diagnosis of CRBSI caused by “M. toneyamachuris” was made. Our findings suggest that genomic sequencing is available for the accurate identification of NTM species.
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b细胞前体急性淋巴细胞白血病男童新近提出的“斜眼分枝杆菌”导管相关血流感染
本报告描述了一名6岁男孩在治疗b细胞前体急性淋巴细胞白血病期间发生非结核分枝杆菌(NTM)导管相关性血流感染(CRBSI)。在开始治疗前插入希克曼导尿管。他在化疗期间发烧,并从导管中抽取了血液培养。革兰氏染色发现革兰氏阳性杆菌模糊,Ziehl-Neelsen染色呈阳性,基质辅助激光解吸/电离飞行时间质谱法鉴定为phocaicum mucogenicum组。开始给予克拉霉素和阿米卡星,并拔除希克曼导管。我们进行了基因组测序以获得准确的鉴定,证明该微生物被鉴定为“M”。“Toneyamachuris”由平均核苷酸同一性指数计算。最后,对CRBSI的临床诊断。《Toneyamachuris》诞生了。我们的研究结果表明,基因组测序可用于准确鉴定NTM物种。
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来源期刊
CiteScore
5.30
自引率
3.40%
发文量
149
审稿时长
56 days
期刊介绍: Diagnostic Microbiology and Infectious Disease keeps you informed of the latest developments in clinical microbiology and the diagnosis and treatment of infectious diseases. Packed with rigorously peer-reviewed articles and studies in bacteriology, immunology, immunoserology, infectious diseases, mycology, parasitology, and virology, the journal examines new procedures, unusual cases, controversial issues, and important new literature. Diagnostic Microbiology and Infectious Disease distinguished independent editorial board, consisting of experts from many medical specialties, ensures you extensive and authoritative coverage.
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