Structural development of curcumin: A natural product arsenal for diverse therapeutic targets- seizing opportunities through serendipity and rational design

IF 4 2区化学 Q2 CHEMISTRY, PHYSICAL Journal of Molecular Structure Pub Date : 2024-11-23 DOI:10.1016/j.molstruc.2024.140815

Mahmood Ahmed , Sehar Basheer , Mohammed H. AL Mughram , Dure Najaf Iqbal , Shaista Qamar , Ahmad Saeed , Rida Batool , Mudassar Sanaullah , Hussain Raza , Riaz Hussain

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Abstract

Curcumin, a polyphenolic compound found in turmeric, has demonstrated various therapeutic properties such as anti-inflammatory, antioxidant, and anti-cancer effects. However, its clinical application is limited by its poor bioavailability, which stems from its low solubility, rapid metabolism, and quick systemic elimination. Modifications in the chemical structure of curcumin have been employed to improve its pharmacokinetic properties. Incorporating various functional groups into the curcumin molecule can significantly impact its activity. Creating hybrid molecules by combining curcumin with other bioactive compounds can result in synergistic effects. The structural development of curcumin aims to enhance its therapeutic efficacy by improving its bioavailability, stability, and specific activity against various diseases. These new molecules could offer improved potency and target specific therapeutic areas more effectively. This review explores the serendipitous discoveries and rational design approaches that have contributed to curcumin's development as a potent therapeutic agent which can unlock a broader spectrum of therapeutic applications.

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姜黄素的结构发展：多种治疗靶点的天然产物库-通过偶然发现和合理设计抓住机会

姜黄素是一种在姜黄中发现的多酚类化合物，具有多种治疗特性，如抗炎、抗氧化和抗癌作用。但其溶解度低、代谢快、全身清除快，生物利用度差，限制了其临床应用。通过改变姜黄素的化学结构来改善其药代动力学性质。在姜黄素分子中加入不同的官能团可以显著影响其活性。通过将姜黄素与其他生物活性化合物结合产生杂交分子可以产生协同效应。姜黄素的结构发展旨在通过提高其生物利用度、稳定性和抗多种疾病的特异性活性来提高其治疗效果。这些新分子可以提供更好的效力，更有效地针对特定的治疗领域。这篇综述探讨了姜黄素的偶然发现和合理的设计方法，这些发现有助于姜黄素作为一种有效的治疗药物的发展，可以开启更广泛的治疗应用。

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来源期刊

Journal of Molecular Structure 化学-物理化学

CiteScore

7.10

自引率

15.80%

发文量

2384

审稿时长

45 days

期刊介绍： The Journal of Molecular Structure is dedicated to the publication of full-length articles and review papers, providing important new structural information on all types of chemical species including: • Stable and unstable molecules in all types of environments (vapour, molecular beam, liquid, solution, liquid crystal, solid state, matrix-isolated, surface-absorbed etc.) • Chemical intermediates • Molecules in excited states • Biological molecules • Polymers. The methods used may include any combination of spectroscopic and non-spectroscopic techniques, for example: • Infrared spectroscopy (mid, far, near) • Raman spectroscopy and non-linear Raman methods (CARS, etc.) • Electronic absorption spectroscopy • Optical rotatory dispersion and circular dichroism • Fluorescence and phosphorescence techniques • Electron spectroscopies (PES, XPS), EXAFS, etc. • Microwave spectroscopy • Electron diffraction • NMR and ESR spectroscopies • Mössbauer spectroscopy • X-ray crystallography • Charge Density Analyses • Computational Studies (supplementing experimental methods) We encourage publications combining theoretical and experimental approaches. The structural insights gained by the studies should be correlated with the properties, activity and/ or reactivity of the molecule under investigation and the relevance of this molecule and its implications should be discussed.