A systematic review of the use of GLP-1 receptor agonists in surgery

IF 2.7 3区 医学 Q1 SURGERY American journal of surgery Pub Date : 2025-02-01 Epub Date: 2024-11-26 DOI:10.1016/j.amjsurg.2024.116119
Jacqueline M.H. Ihnat , Heloise De Baun , Gabriel Carrillo , Alna Dony , Thayer J. Mukherjee , Haripriya S. Ayyala
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Abstract

Background

Surgeons are likely to encounter patients on GLP-1 receptor agonists (GLP-1RAs) and should be aware of any associated risks or complications. Here we review the existing literature on GLP-1RA use as it pertains to non-bariatric surgeons.

Methods

A systematic review was conducted following PRISMA 2020 guidelines. Three databases were queried for articles discussing the use of GLP-1RAs in a surgical context. Articles went through two rounds of manual screening.

Results

21 articles were included in analysis, which found that pre-operatively, GLP-1RAs can aid patients in meeting the BMI threshold for surgery. Peri-operatively, GLP-1RAs were associated with improved glycemic control and lower intraoperative insulin use. Complications such as delayed gastric emptying and increased rates of hypoglycemic events were reported.

Conclusion

Surgeons may leverage GLP-1RAs to help prepare patients for surgery and should understand potential surgical complications associated with the use of these medications and to screen preoperative patients appropriately.
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GLP-1受体激动剂在外科手术中应用的系统综述
背景:外科医生可能会遇到使用GLP-1受体激动剂(GLP-1RAs)的患者,并应注意任何相关的风险或并发症。在这里,我们回顾了关于GLP-1RA在非减肥外科医生中的应用的现有文献。方法按照PRISMA 2020指南进行系统评价。在三个数据库中查询了讨论GLP-1RAs在外科环境中使用的文章。文章经过了两轮人工筛选。结果21篇文章纳入分析,发现术前GLP-1RAs可以帮助患者达到手术所需的BMI阈值。围手术期,GLP-1RAs与改善血糖控制和降低术中胰岛素使用相关。据报道,并发症如胃排空延迟和低血糖事件发生率增加。结论外科医生可以利用GLP-1RAs帮助患者做好手术准备,并应了解与使用这些药物相关的潜在手术并发症,并适当筛查术前患者。
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来源期刊
CiteScore
5.00
自引率
6.70%
发文量
570
审稿时长
56 days
期刊介绍: The American Journal of Surgery® is a peer-reviewed journal designed for the general surgeon who performs abdominal, cancer, vascular, head and neck, breast, colorectal, and other forms of surgery. AJS is the official journal of 7 major surgical societies* and publishes their official papers as well as independently submitted clinical studies, editorials, reviews, brief reports, correspondence and book reviews.
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