Colloid Bodies in Cutaneous Basal Cell Carcinoma: Clinical and Histologic Correlates—An Analysis of 405 Cases

IF 1.1 4区医学 Q3 DERMATOLOGY Journal of Cutaneous Pathology Pub Date : 2024-11-28 DOI:10.1111/cup.14755

Ruben Oganesyan, Steven R. Tahan

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Abstract

Background

Colloid bodies (CB), also known as Civatte bodies, are commonly seen in inflammatory dermatoses and are thought to represent cell degeneration. No studies have investigated the incidence and clinical associations of CB in cutaneous basal cell carcinoma (BCC). The aim of this study is to assess the incidence of CB in BCC lesions and analyze their clinical associations.

Methods

Four hundred and five sequential cases of cutaneous BCC from 396 patients diagnosed from 1/1/2023 to 12/31/2023 in our institution were studied for the presence of CB. Only cases of BCC with a single growth pattern were included. BCC subtype, patient age, location of the lesion, history of previous BCC at other site, smoking history, and allergy history were collected. Cases with and without CB were compared for each parameter using the paired t-test for age and the Chi-square test for categorical data.

Results

Patients were grouped based on the presence of CB into a study group (57 cases) and control group with no CB (348 cases). CB were identified in 14% (57/405) of BCCs. 19% (54/281) of nodular, 12.5% (1/8) of infiltrative, and 1.7% (2/116) of superficial type BCCs had CB. BCC with CB were more common on the face/scalp than other sites (66.7% vs. 34.2%, p < 0.001). Patients with CB were older (median 72 vs. 68 years ±12, p = 0.04), predominantly male (63% vs. 47%, p = 0.02), more frequently had a prior BCC (0.61% vs. 0.38%, p = 0.012), and did not differ in smoking history compared to the control cohort.

Conclusions

We identified CB in 14% of BCCs studied, most commonly in nodular, followed by infiltrative, and least often superficial type. After cohort matching, significant clinical associations of CB in BCC were sun-exposed location and personal history of one or more prior BCC at other site(s). Their pathogenesis is not known, however their presence suggests tumor regression, which may potentially be exploited for new therapies in a subset of patients.

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皮肤基底细胞癌的胶体体：临床和组织学相关性——405例分析。

背景：胶体体（CB），也被称为Civatte体，常见于炎症性皮肤病，被认为是细胞变性的代表。没有研究调查CB在皮肤基底细胞癌（BCC）中的发病率和临床关系。本研究的目的是评估BCC病变中CB的发生率并分析其临床相关性。方法：对我院2023年1月1日至2023年12月31日诊断的396例皮肤基底细胞癌患者中的405例进行连续研究，以确定是否存在基底细胞癌。仅包括单一生长模式的BCC病例。收集BCC亚型、患者年龄、病变部位、其他部位既往BCC病史、吸烟史、过敏史。使用年龄配对t检验和分类数据卡方检验比较有和没有CB的病例的每个参数。结果：根据CB的存在将患者分为研究组（57例）和无CB的对照组（348例）。14%（57/405）的bcc被鉴定为CB。19%（54/281）的结节型、12.5%（1/8）的浸润型和1.7%（2/116）的浅表型bcc有CB。BCC合并CB在面部/头皮比其他部位更常见（66.7% vs. 34.2%, p）结论：我们在14%的BCC中发现了CB，最常见的是结节型，其次是浸润型，最不常见的是浅表型。在队列匹配后，BCC中CB的显著临床关联是暴露在阳光下的位置和在其他部位有一个或多个既往BCC的个人病史。它们的发病机制尚不清楚，但它们的存在表明肿瘤消退，这可能潜在地用于部分患者的新疗法。

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来源期刊

Journal of Cutaneous Pathology 医学-病理学

CiteScore

3.20

自引率

5.90%

发文量

174

审稿时长

3-8 weeks

期刊介绍： Journal of Cutaneous Pathology publishes manuscripts broadly relevant to diseases of the skin and mucosae, with the aims of advancing scientific knowledge regarding dermatopathology and enhancing the communication between clinical practitioners and research scientists. Original scientific manuscripts on diagnostic and experimental cutaneous pathology are especially desirable. Timely, pertinent review articles also will be given high priority. Manuscripts based on light, fluorescence, and electron microscopy, histochemistry, immunology, molecular biology, and genetics, as well as allied sciences, are all welcome, provided their principal focus is on cutaneous pathology. Publication time will be kept as short as possible, ensuring that articles will be quickly available to all interested in this speciality.