Advanced 3D-DXA insights into bone density changes in hyperparathyroidism.

IF 1.8 Q4 ENDOCRINOLOGY & METABOLISM Journal of Diabetes and Metabolic Disorders Pub Date : 2024-08-29 eCollection Date: 2024-12-01 DOI:10.1007/s40200-024-01487-3
Francesco Saverio Guerra, Nicola Palladino, Renaud Winzenrieth, Giuseppe Guglielmi
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Abstract

Objectives: Primary hyperparathyroidism (PHPT) is a disorder marked by chronic parathyroid hormone hypersecretion, which affects bone turnover and remodelling processes. With a loss of bone density and an increase in bone porosity, the cortical compartment is most severely impacted. The study's goal is to assess PHPT's effects on the volumetric bone mineral density (vBMD) of the femur's trabecular compartment as well as the vBMD and thickness of the cortical bone.

Methods: This is a retrospective case-control study, valuating age, biochemical doses, anthropometric measurements, and bone measurements. Between 2011 and 2016, 74 Caucasian Italian women and men with PHPT were sought out. Biochemical analyses were added to bone mineral density (BMD) values found in the lumbar spine and femoral neck. Proximal femur parameters such as cortical and trabecular volumetric (v) BMD, cortical thickness (CTh) and surface (s) BMD were analyzed by 3D-DXA software (3D-SHAPER Medical, Spain).

Results: The findings showed a negative correlation between PHPT patients and controls, which was equally affecting the cortical and trabecular compartments. This correlation was especially evident in the areal BMD (aBMD) and vBMD measurements. Nonetheless, no appreciable correlation was found between the cortical level and the thickness of the cortical bone.

Conclusions: Parathormone (PHT) levels had an adverse effect on the cortical, trabecular volumetric density in this investigation, as was expected. Cortical thickness, however, is unaffected significantly. The literature and these findings are consistent.

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先进的3D-DXA洞察甲状旁腺功能亢进的骨密度变化。
目的:原发性甲状旁腺功能亢进(PHPT)是一种以慢性甲状旁腺激素分泌过多为特征的疾病,它影响骨的转换和重塑过程。随着骨密度的减少和骨孔隙度的增加,皮质腔室受到最严重的影响。该研究的目的是评估PHPT对股骨小梁室体积骨矿物质密度(vBMD)以及vBMD和皮质骨厚度的影响。方法:这是一项回顾性病例对照研究,评估年龄、生化剂量、人体测量和骨骼测量。在2011年至2016年期间,研究人员寻找了74名患有PHPT的意大利白人女性和男性。在腰椎和股骨颈发现的骨密度(BMD)值中加入了生化分析。通过3D-DXA软件(3D-SHAPER Medical,西班牙)分析股骨近端参数,如皮质和小梁体积骨密度(v)、皮质厚度(CTh)和表面骨密度(s)。结果:研究结果显示PHPT患者与对照组之间呈负相关,其对皮质和小梁间室的影响相同。这种相关性在面积骨密度(aBMD)和vBMD测量中尤为明显。然而,在皮质水平和皮质骨厚度之间没有发现明显的相关性。结论:正如预期的那样,在这项研究中,甲状旁激素(PHT)水平对皮质、小梁体积密度有不利影响。然而,皮质厚度明显不受影响。文献和这些发现是一致的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Journal of Diabetes and Metabolic Disorders
Journal of Diabetes and Metabolic Disorders Medicine-Internal Medicine
CiteScore
4.80
自引率
3.60%
发文量
210
期刊介绍: Journal of Diabetes & Metabolic Disorders is a peer reviewed journal which publishes original clinical and translational articles and reviews in the field of endocrinology and provides a forum of debate of the highest quality on these issues. Topics of interest include, but are not limited to, diabetes, lipid disorders, metabolic disorders, osteoporosis, interdisciplinary practices in endocrinology, cardiovascular and metabolic risk, aging research, obesity, traditional medicine, pychosomatic research, behavioral medicine, ethics and evidence-based practices.As of Jan 2018 the journal is published by Springer as a hybrid journal with no article processing charges. All articles published before 2018 are available free of charge on springerlink.Unofficial 2017 2-year Impact Factor: 1.816.
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