Exploring genetic signatures of obesity: hub genes and miRNAs unveiled through comprehensive bioinformatic analysis.

IF 1.8 Q4 ENDOCRINOLOGY & METABOLISM Journal of Diabetes and Metabolic Disorders Pub Date : 2024-09-03 eCollection Date: 2024-12-01 DOI:10.1007/s40200-024-01490-8

Mahdieh Tamkini, Mitra Nourbakhsh, Monireh Movahedi, Abolfazl Golestani

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Abstract

Objectives: Adipogenesis, the process of fat accumulation in adipose tissue, is closely linked to obesity, a condition characterized by excessive fat storage. Genetic factors significantly contribute to an individual's susceptibility to adipogenesis and the development of obesity.

Methods: In this study, we conducted a comprehensive bioinformatic analysis, including Weighted Gene Co-expression Analysis, differentially expressed gene analysis, and protein-protein interaction analysis, to identify hub genes and miRNAs associated with obesity.

Results: Our findings highlight the potential involvement of genes such as ATP5F1A, FN1, CCl2, RPS14, and RPS16, as well as miRNAs including hsa-miR-6844, hsa-miR-4528, hsa-miR-3686, hsa-miR-3124-3p, hsa-miR-381-3p, and hsa-miR-300 in obesity.

Conclusions: The findings from this study contribute to the growing knowledge of adipogenesis and obesity genetics, and provide potential biomarkers for further investigation and translation into clinical or research applications.

Graphical abstract:

Supplementary information: The online version contains supplementary material available at 10.1007/s40200-024-01490-8.

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探索肥胖的遗传特征：通过综合生物信息学分析揭示枢纽基因和mirna。

目的：脂肪生成是脂肪组织中脂肪积累的过程，与肥胖密切相关，肥胖是一种以脂肪过度储存为特征的疾病。遗传因素在很大程度上影响了个体对脂肪形成和肥胖的易感性。方法：本研究通过加权基因共表达分析、差异表达基因分析、蛋白-蛋白相互作用分析等综合生物信息学分析，鉴定与肥胖相关的枢纽基因和mirna。结果：我们的研究结果强调了ATP5F1A、FN1、CCl2、RPS14和RPS16等基因以及hsa-miR-6844、hsa-miR-4528、hsa-miR-3686、hsa-miR-3124-3p、hsa-miR-381-3p和hsa-miR-300等mirna与肥胖的潜在关系。结论：本研究的发现有助于增加对脂肪形成和肥胖遗传学的了解，并为进一步研究和转化为临床或研究应用提供潜在的生物标志物。图片摘要：补充资料：在线版本包含补充资料，网址为10.1007/s40200-024-01490-8。

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来源期刊

Journal of Diabetes and Metabolic Disorders Medicine-Internal Medicine

CiteScore

4.80

自引率

3.60%

发文量

210

期刊介绍： Journal of Diabetes & Metabolic Disorders is a peer reviewed journal which publishes original clinical and translational articles and reviews in the field of endocrinology and provides a forum of debate of the highest quality on these issues. Topics of interest include, but are not limited to, diabetes, lipid disorders, metabolic disorders, osteoporosis, interdisciplinary practices in endocrinology, cardiovascular and metabolic risk, aging research, obesity, traditional medicine, pychosomatic research, behavioral medicine, ethics and evidence-based practices.As of Jan 2018 the journal is published by Springer as a hybrid journal with no article processing charges. All articles published before 2018 are available free of charge on springerlink.Unofficial 2017 2-year Impact Factor: 1.816.