Evaluate the Role of Phosphodiesterase, Myeloperoxidase and Iron in Oral Cancer.

Q2 Medicine Asian Pacific Journal of Cancer Prevention Pub Date : 2024-11-01 DOI:10.31557/APJCP.2024.25.11.3921

Madhura M M, Pushparaj Shetty, Naresh Yajamanam, Shwetha A Neralakatte, Preethi Hegde, Nireeksha Shetty, Mehaboob Ali, Kundubai A, Mamatha Kshatriya

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引用次数: 0

Abstract

Objective: The present study aimed to estimate the levels of phosphodiesterase (PDE), myeloperoxidase (MPO) and iron levels in patients with oral cancer.

Method: 50 patients reporting to the Department of Oral Medicine and Radiology A.B. Shetty Memorial Institute of Dental Sciences, Deralakatte, Mangalore were recruited for the study after taking informed consent. The study group consists of 50 control groups with no complications and 50 oral cancer patients. A 5 ml venous Blood sample was taken, centrifuged and serum was collected for subsequent analysis. 50 normal control samples were also collected for comparison purposes. PDE, MPO and iron levels were estimated.

Results: PDE levels were significantly elevated in the case group compared to the control. MPO and iron levels were significantly reduced in the case group compared to the control.

Conclusion: Immunological and biochemical assessment of oral precancer and cancer patients may help in earlier diagnosis and/or prognosis of these lesions. This may also serve in predicting the malignant potential of the pre-malignant lesions.

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评价磷酸二酯酶、髓过氧化物酶和铁在口腔癌中的作用。

目的：本研究旨在评估口腔癌患者的磷酸二酯酶（PDE）、髓过氧化物酶（MPO）和铁水平。方法：经知情同意后，在Mangalore Deralakatte市A.B. Shetty纪念口腔科学研究所口腔医学和放射科招募50例患者参加研究。研究组由50例无并发症的对照组和50例口腔癌患者组成。取静脉血5 ml，离心，取血清分析。另外还收集了50个正常对照样本进行比较。测定PDE、MPO和铁含量。结果：与对照组相比，病例组PDE水平显著升高。与对照组相比，病例组的MPO和铁水平显著降低。结论：对口腔癌前病变和癌前病变患者进行免疫学和生化检查有助于早期诊断和/或预后。这也可用于预测癌前病变的恶性潜能。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Asian Pacific Journal of Cancer Prevention 医学-肿瘤学

CiteScore

2.80

自引率

0.00%

发文量

779

审稿时长

3 months

期刊介绍： Cancer is a very complex disease. While many aspects of carcinoge-nesis and oncogenesis are known, cancer control and prevention at the community level is however still in its infancy. Much more work needs to be done and many more steps need to be taken before effective strategies are developed. The multidisciplinary approaches and efforts to understand and control cancer in an effective and efficient manner, require highly trained scientists in all branches of the cancer sciences, from cellular and molecular aspects to patient care and palliation. The Asia Pacific Organization for Cancer Prevention (APOCP) and its official publication, the Asia Pacific Journal of Cancer Prevention (APJCP), have served the community of cancer scientists very well and intends to continue to serve in this capacity to the best of its abilities. One of the objectives of the APOCP is to provide all relevant and current scientific information on the whole spectrum of cancer sciences. They aim to do this by providing a forum for communication and propagation of original and innovative research findings that have relevance to understanding the etiology, progression, treatment, and survival of patients, through their journal. The APJCP with its distinguished, diverse, and Asia-wide team of editors, reviewers, and readers, ensure the highest standards of research communication within the cancer sciences community across Asia as well as globally. The APJCP publishes original research results under the following categories: -Epidemiology, detection and screening. -Cellular research and bio-markers. -Identification of bio-targets and agents with novel mechanisms of action. -Optimal clinical use of existing anti-cancer agents, including combination therapies. -Radiation and surgery. -Palliative care. -Patient adherence, quality of life, satisfaction. -Health economic evaluations.