{"title":"Delineation of hub genes related to ferroptosis and radiosensitivity in breast cancer with three identified subtypes.","authors":"Mao Mao, Yichao Zhuang, Haitao Yu","doi":"10.1080/10255842.2024.2433113","DOIUrl":null,"url":null,"abstract":"<p><p>This study aimed to explore the roles of radiotherapy-sensitive and ferroptosis genes in breast cancer (BRCA). Genes differentially expressed pre- and post-radiotherapy from the GSE59733 dataset were intersected with ferroptosis-related genes. Through a protein-protein interaction network, 10 hub genes were identified. BRCA patients were categorized into three clusters, with cluster 1 and cluster 2 showing the most significant survival difference. Cluster 1 demonstrated higher immune infiltration levels but poorer response to immune therapy compared to cluster 2. Moreover, cluster 1 and cluster 2 exhibited sensitivity to different drugs. These 10 hub genes can effectively classify patients and suggest potential drugs.</p>","PeriodicalId":50640,"journal":{"name":"Computer Methods in Biomechanics and Biomedical Engineering","volume":" ","pages":"1-16"},"PeriodicalIF":1.7000,"publicationDate":"2024-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Computer Methods in Biomechanics and Biomedical Engineering","FirstCategoryId":"5","ListUrlMain":"https://doi.org/10.1080/10255842.2024.2433113","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"COMPUTER SCIENCE, INTERDISCIPLINARY APPLICATIONS","Score":null,"Total":0}
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Abstract
This study aimed to explore the roles of radiotherapy-sensitive and ferroptosis genes in breast cancer (BRCA). Genes differentially expressed pre- and post-radiotherapy from the GSE59733 dataset were intersected with ferroptosis-related genes. Through a protein-protein interaction network, 10 hub genes were identified. BRCA patients were categorized into three clusters, with cluster 1 and cluster 2 showing the most significant survival difference. Cluster 1 demonstrated higher immune infiltration levels but poorer response to immune therapy compared to cluster 2. Moreover, cluster 1 and cluster 2 exhibited sensitivity to different drugs. These 10 hub genes can effectively classify patients and suggest potential drugs.
期刊介绍：
The primary aims of Computer Methods in Biomechanics and Biomedical Engineering are to provide a means of communicating the advances being made in the areas of biomechanics and biomedical engineering and to stimulate interest in the continually emerging computer based technologies which are being applied in these multidisciplinary subjects. Computer Methods in Biomechanics and Biomedical Engineering will also provide a focus for the importance of integrating the disciplines of engineering with medical technology and clinical expertise. Such integration will have a major impact on health care in the future.
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