Timing of meal replacement on body weight: a multicenter open-labeled randomized trial.

IF 2.9 3区医学 Q2 ENDOCRINOLOGY & METABOLISM Endocrine Pub Date : 2025-04-01 Epub Date: 2024-11-29 DOI:10.1007/s12020-024-04118-2

Jialu Wang, Yi Xiang, Zhiqi Chen, Wenyi Lu, Yiquan Zhou, Xiaomeng Mao, Molian Tang, Jing Zou, Anqi Song, Qingya Tang, Renying Xu

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Abstract

Purpose: We aim to evaluate the effects of partial meal replacement (MR) with different timing of MR on body weight in Chinese adults.

Methods: A multicenter open-labeled, randomized, parallel study was performed. Participants were randomly assigned to receive partial MR at breakfast and lunch or breakfast and dinner for 16 weeks. The primary outcome was the absolute change in body weight between baseline and the end of the intervention. The BMI of participants is between 24.0 kg/m² and 35.0 kg/m², without a history of diabetes, hypertension, or gout, and whose baseline blood pressure, fasting blood glucose, serum level of glycated hemoglobin A1c, uric acid, and liver enzymes within the pre-determined range, were recruited.

Results: A total number of 153 individuals were included in the analysis (106 females and 47 males; mean age 32.6 ± 6.7 years, mean BMI 28.5 ± 2.8 kg/m² at baseline). Partial MR for 16 weeks resulted in significant body weight loss (-5.1 kg, 95% CI: -5.8, -4.5 kg), decrease of waist (-4.8 cm; 95% CI: -5.5 cm, -4.1 cm) and hip circumference (-4.3 cm; 95% CI: -4.9 cm, -3.8 cm), and loss of body fat (-4.1 kg; 95% CI: -4.7 kg, -3.6 kg). About half of the participants (51.6%) achieved the goal of losing 5% of baseline body weight or more. Timings of MR (breakfast and lunch vs. breakfast and dinner) generated similar results.

Conclusion: Partial MR resulted in significant improvements in anthropometric data, body fat, and most metabolic variables while different MR timing generated similar results.

Trial registration: The study was registered at https://www.chictr.org.cn/showproj.html?proj=47475 (ChiCTR2100042637).

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代餐时间对体重的影响：一项多中心开放标签随机试验。

目的：我们旨在评估不同时间的部分代餐对中国成年人体重的影响。方法：采用多中心、开放标记、随机、平行研究。参与者被随机分配在早餐和午餐或早餐和晚餐接受部分磁共振成像，为期16周。主要结果是基线和干预结束之间体重的绝对变化。参与者的BMI在24.0 kg/m2至35.0 kg/m2之间，无糖尿病、高血压或痛风病史，基线血压、空腹血糖、血清糖化血红蛋白A1c、尿酸和肝酶水平均在预先确定的范围内。结果：共纳入153只个体，其中雌性106只，雄性47只；平均年龄32.6±6.7岁，基线时平均BMI为28.5±2.8 kg/m2)。部分MR治疗16周后，体重显著减轻（-5.1 kg, 95% CI: -5.8, -4.5 kg），腰围减少(-4.8 cm；95% CI: -5.5 cm, -4.1 cm)和臀围(-4.3 cm；95% CI: -4.9 cm, -3.8 cm)，体脂减少(-4.1 kg；95% CI: -4.7 kg, -3.6 kg)。大约一半的参与者（51.6%）达到了减少基线体重5%或更多的目标。MR的时间安排（早餐和午餐vs早餐和晚餐）也产生了类似的结果。结论：部分MR导致人体测量数据、体脂和大多数代谢变量的显著改善，而不同MR时间产生相似的结果。试验注册：本研究注册于https://www.chictr.org.cn/showproj.html?proj=47475 （ChiCTR2100042637）。

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来源期刊

Endocrine ENDOCRINOLOGY & METABOLISM-

CiteScore

6.50

自引率

5.40%

发文量

295

审稿时长

1.5 months

期刊介绍： Well-established as a major journal in today’s rapidly advancing experimental and clinical research areas, Endocrine publishes original articles devoted to basic (including molecular, cellular and physiological studies), translational and clinical research in all the different fields of endocrinology and metabolism. Articles will be accepted based on peer-reviews, priority, and editorial decision. Invited reviews, mini-reviews and viewpoints on relevant pathophysiological and clinical topics, as well as Editorials on articles appearing in the Journal, are published. Unsolicited Editorials will be evaluated by the editorial team. Outcomes of scientific meetings, as well as guidelines and position statements, may be submitted. The Journal also considers special feature articles in the field of endocrine genetics and epigenetics, as well as articles devoted to novel methods and techniques in endocrinology. Endocrine covers controversial, clinical endocrine issues. Meta-analyses on endocrine and metabolic topics are also accepted. Descriptions of single clinical cases and/or small patients studies are not published unless of exceptional interest. However, reports of novel imaging studies and endocrine side effects in single patients may be considered. Research letters and letters to the editor related or unrelated to recently published articles can be submitted. Endocrine covers leading topics in endocrinology such as neuroendocrinology, pituitary and hypothalamic peptides, thyroid physiological and clinical aspects, bone and mineral metabolism and osteoporosis, obesity, lipid and energy metabolism and food intake control, insulin, Type 1 and Type 2 diabetes, hormones of male and female reproduction, adrenal diseases pediatric and geriatric endocrinology, endocrine hypertension and endocrine oncology.