Scientific Advances in Cancer Detection Using Raman Spectroscopy.

Q2 Medicine Asian Pacific Journal of Cancer Prevention Pub Date : 2024-11-01 DOI:10.31557/APJCP.2024.25.11.3977

Gourav Kumar Jain, Rajni Verma, Arun Chougule, Bharti Singh

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Abstract

Aim: The present study is focused to investigate the role of Raman spectroscopy (RM) for cancer detection.

Methods: In this review, we explored a number of scientific databases including PubMed, Web of Science, Embase and Google Scholar for research studies on Raman spectroscopy for diagnosing cancer. We reported key outcomes of research studies conducted involving Raman spectroscopy for diagnosis of cancer and highlighting the potential of novel Raman spectroscopy for diagnosing cancer in our review.

Results: Based on the available evidence it can be strongly concluded that Raman spectroscopy provide significant information for diagnosing cancer. Numerous comprehensive studies involving living cells in vitro, in-vivo animal models and ex-vivo human tissues pre-clinical Raman experiments are conducted on biological specimens for almost every type of cancer for diagnosing cancer demonstrating the potential for clinical use of Raman spectroscopy. Furthermore, the in-vivo Raman handheld probes are developed and experimentally used for real time detection of human breast and brain tumors with significant sensitivity and specificity. However, it will be important and challenging to explore relevant Raman biomarkers for other types of cancer as well, to distinguish cancer.

Conclusion: Raman spectroscopy is an effective method and valuable tool in the field of cancer diagnostics. The Raman spectroscopy deserves a place for future in clinics for rapid cancer diagnostics.

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利用拉曼光谱检测癌症的科学进展。

目的：探讨拉曼光谱（Raman spectroscopy， RM）在肿瘤检测中的作用。方法：利用PubMed、Web of Science、Embase、谷歌Scholar等科学数据库，开展拉曼光谱诊断癌症的相关研究。在我们的综述中，我们报道了涉及拉曼光谱诊断癌症的研究的关键结果，并强调了新型拉曼光谱诊断癌症的潜力。结果：基于现有的证据，可以强有力地得出结论，拉曼光谱为癌症诊断提供了重要的信息。在几乎每一种癌症的生物标本上都进行了大量涉及活细胞体外、体内动物模型和离体人体组织的临床前拉曼实验的综合研究，以诊断癌症，展示了拉曼光谱在临床应用的潜力。此外，研究开发了体内手持式拉曼探针，并将其实验应用于人类乳腺和脑肿瘤的实时检测，具有显著的灵敏度和特异性。然而，探索其他类型癌症的相关拉曼生物标志物，以区分癌症将是重要的和具有挑战性的。结论：拉曼光谱在癌症诊断领域是一种有效的方法和有价值的工具。拉曼光谱在未来的临床快速癌症诊断中应该占有一席之地。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Asian Pacific Journal of Cancer Prevention 医学-肿瘤学

CiteScore

2.80

自引率

0.00%

发文量

779

审稿时长

3 months

期刊介绍： Cancer is a very complex disease. While many aspects of carcinoge-nesis and oncogenesis are known, cancer control and prevention at the community level is however still in its infancy. Much more work needs to be done and many more steps need to be taken before effective strategies are developed. The multidisciplinary approaches and efforts to understand and control cancer in an effective and efficient manner, require highly trained scientists in all branches of the cancer sciences, from cellular and molecular aspects to patient care and palliation. The Asia Pacific Organization for Cancer Prevention (APOCP) and its official publication, the Asia Pacific Journal of Cancer Prevention (APJCP), have served the community of cancer scientists very well and intends to continue to serve in this capacity to the best of its abilities. One of the objectives of the APOCP is to provide all relevant and current scientific information on the whole spectrum of cancer sciences. They aim to do this by providing a forum for communication and propagation of original and innovative research findings that have relevance to understanding the etiology, progression, treatment, and survival of patients, through their journal. The APJCP with its distinguished, diverse, and Asia-wide team of editors, reviewers, and readers, ensure the highest standards of research communication within the cancer sciences community across Asia as well as globally. The APJCP publishes original research results under the following categories: -Epidemiology, detection and screening. -Cellular research and bio-markers. -Identification of bio-targets and agents with novel mechanisms of action. -Optimal clinical use of existing anti-cancer agents, including combination therapies. -Radiation and surgery. -Palliative care. -Patient adherence, quality of life, satisfaction. -Health economic evaluations.