{"title":"Regional Disparities in the Impact of Human Papillomavirus-Induced Lesions after 10 Years of HPV Vaccination Program in Brazil.","authors":"Adriana V Graca, Leila Cristina Soares Brollo","doi":"10.31557/APJCP.2024.25.11.3755","DOIUrl":null,"url":null,"abstract":"<p><strong>Background and objective: </strong>Human papillomavirus (HPV) causes almost all cases of cervical cancer and its prevalence can be significantly reduced by vaccines. This study aimed to compare the prevalence of preneoplastic and neoplastic uterine cervix lesions in the cytology of Brazilian women aged 20-24 yr before and after the HPV vaccination campaign. The study also correlates these findings with the proportional coverage of first and second doses for this population.</p><p><strong>Methods: </strong>An ecological study was conducted and data from DATASUS were analyzed from 2020 to 2024. Data were collected from women aged 20-24 yr who had oncotic pap smears between 2020 and 2024, and the prevalence ratios (PRs) were calculated in relation to 2020.</p><p><strong>Results: </strong>Following the vaccination program, the prevalence rate of tests with HPV-induced lesions in Brazil and the north, southeast, and south regions decreased by 0.85, 0.75, and 0.83, respectively, in 2023. No significant reductions were observed in the northeast and central-west regions.</p><p><strong>Conclusion: </strong>Although the second dose had reduced coverage, HPV-induced lesions were observed to decrease in Brazil and the north, southeast, and south after 10 yr of the beginning of the vaccination program. Decrease in HPV-induced lesions over time after vaccination did not follow similar trend in the northeast or central-west regions as in other parts.</p>","PeriodicalId":55451,"journal":{"name":"Asian Pacific Journal of Cancer Prevention","volume":"25 11","pages":"3755-3759"},"PeriodicalIF":0.0000,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Asian Pacific Journal of Cancer Prevention","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.31557/APJCP.2024.25.11.3755","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 0
Abstract
Background and objective: Human papillomavirus (HPV) causes almost all cases of cervical cancer and its prevalence can be significantly reduced by vaccines. This study aimed to compare the prevalence of preneoplastic and neoplastic uterine cervix lesions in the cytology of Brazilian women aged 20-24 yr before and after the HPV vaccination campaign. The study also correlates these findings with the proportional coverage of first and second doses for this population.
Methods: An ecological study was conducted and data from DATASUS were analyzed from 2020 to 2024. Data were collected from women aged 20-24 yr who had oncotic pap smears between 2020 and 2024, and the prevalence ratios (PRs) were calculated in relation to 2020.
Results: Following the vaccination program, the prevalence rate of tests with HPV-induced lesions in Brazil and the north, southeast, and south regions decreased by 0.85, 0.75, and 0.83, respectively, in 2023. No significant reductions were observed in the northeast and central-west regions.
Conclusion: Although the second dose had reduced coverage, HPV-induced lesions were observed to decrease in Brazil and the north, southeast, and south after 10 yr of the beginning of the vaccination program. Decrease in HPV-induced lesions over time after vaccination did not follow similar trend in the northeast or central-west regions as in other parts.
期刊介绍：
Cancer is a very complex disease. While many aspects of carcinoge-nesis and oncogenesis are known, cancer control and prevention at the community level is however still in its infancy. Much more work needs to be done and many more steps need to be taken before effective strategies are developed. The multidisciplinary approaches and efforts to understand and control cancer in an effective and efficient manner, require highly trained scientists in all branches of the cancer sciences, from cellular and molecular aspects to patient care and palliation.
The Asia Pacific Organization for Cancer Prevention (APOCP) and its official publication, the Asia Pacific Journal of Cancer Prevention (APJCP), have served the community of cancer scientists very well and intends to continue to serve in this capacity to the best of its abilities. One of the objectives of the APOCP is to provide all relevant and current scientific information on the whole spectrum of cancer sciences. They aim to do this by providing a forum for communication and propagation of original and innovative research findings that have relevance to understanding the etiology, progression, treatment, and survival of patients, through their journal. The APJCP with its distinguished, diverse, and Asia-wide team of editors, reviewers, and readers, ensure the highest standards of research communication within the cancer sciences community across Asia as well as globally.
The APJCP publishes original research results under the following categories:
-Epidemiology, detection and screening.
-Cellular research and bio-markers.
-Identification of bio-targets and agents with novel mechanisms of action.
-Optimal clinical use of existing anti-cancer agents, including combination therapies.
-Radiation and surgery.
-Palliative care.
-Patient adherence, quality of life, satisfaction.
-Health economic evaluations.
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