Neural epidermal growth factor-like 1 protein-positive membranous nephropathy in renal allografts: A series of 6 patients.

IF 8.9 2区 医学 Q1 SURGERY American Journal of Transplantation Pub Date : 2024-11-28 DOI:10.1016/j.ajt.2024.11.026
Anna Kenan, Anila Abraham Kurien, Manuel Gonzalez, Kyrstin Alexander, Anjushree Kumar, Ibrahim Qaqish, Tiffany Caza
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Abstract

Membranous nephropathy (MN) is a major cause of nephrotic syndrome, and neural epidermal growth factor-like 1 protein (NELL1) is the second most common inciting antigen. An increasing number of exposures and diseases have been associated with NELL1+ MN. There are limited data on NELL1 following kidney transplantation with only 1 previously reported case. In this report, we describe 3 cases of recurrent and 3 cases of de novo NELL1+ MN. None of the patients in this series had known triggers of MN, such as malignancy or associated medications (including lipoic acid, bucillamine, tiotropin, or indigenous medicines). This suggests that NELL1, although not a podocyte antigen, may present as an idiopathic disease or transplantation may serve as an exposure for the development of NELL1+ MN.

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6例同种异体肾移植患者的nell1阳性膜性肾病。
膜性肾病(MN)是肾病综合征的主要病因,神经表皮生长因子样1蛋白(NELL1)是第二常见的刺激抗原。越来越多的接触和疾病与NELL1+ MN有关。关于肾移植后NELL1的数据有限,之前只有一例报道。在这里,我们描述了3例复发和3例新发NELL1+ MN。该系列患者中没有已知的MN触发因素,如恶性肿瘤或相关药物(包括硫辛酸、布吉拉胺、硫托平或本土药物)。这表明NELL1虽然不是足细胞抗原,但可能作为特发性疾病出现,或者移植可能作为NELL1+ MN发展的暴露。
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来源期刊
CiteScore
18.70
自引率
4.50%
发文量
346
审稿时长
26 days
期刊介绍: The American Journal of Transplantation is a leading journal in the field of transplantation. It serves as a forum for debate and reassessment, an agent of change, and a major platform for promoting understanding, improving results, and advancing science. Published monthly, it provides an essential resource for researchers and clinicians worldwide. The journal publishes original articles, case reports, invited reviews, letters to the editor, critical reviews, news features, consensus documents, and guidelines over 12 issues a year. It covers all major subject areas in transplantation, including thoracic (heart, lung), abdominal (kidney, liver, pancreas, islets), tissue and stem cell transplantation, organ and tissue donation and preservation, tissue injury, repair, inflammation, and aging, histocompatibility, drugs and pharmacology, graft survival, and prevention of graft dysfunction and failure. It also explores ethical and social issues in the field.
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