Anna Kenan, Anila Abraham Kurien, Manuel Gonzalez, Kyrstin Alexander, Anjushree Kumar, Ibrahim Qaqish, Tiffany Caza
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引用次数: 0
Abstract
Membranous nephropathy (MN) is a major cause of nephrotic syndrome, and neural epidermal growth factor-like 1 protein (NELL1) is the second most common inciting antigen. An increasing number of exposures and diseases have been associated with NELL1+ MN. There are limited data on NELL1 following kidney transplantation with only 1 previously reported case. In this report, we describe 3 cases of recurrent and 3 cases of de novo NELL1+ MN. None of the patients in this series had known triggers of MN, such as malignancy or associated medications (including lipoic acid, bucillamine, tiotropin, or indigenous medicines). This suggests that NELL1, although not a podocyte antigen, may present as an idiopathic disease or transplantation may serve as an exposure for the development of NELL1+ MN.
期刊介绍:
The American Journal of Transplantation is a leading journal in the field of transplantation. It serves as a forum for debate and reassessment, an agent of change, and a major platform for promoting understanding, improving results, and advancing science. Published monthly, it provides an essential resource for researchers and clinicians worldwide.
The journal publishes original articles, case reports, invited reviews, letters to the editor, critical reviews, news features, consensus documents, and guidelines over 12 issues a year. It covers all major subject areas in transplantation, including thoracic (heart, lung), abdominal (kidney, liver, pancreas, islets), tissue and stem cell transplantation, organ and tissue donation and preservation, tissue injury, repair, inflammation, and aging, histocompatibility, drugs and pharmacology, graft survival, and prevention of graft dysfunction and failure. It also explores ethical and social issues in the field.