Relationship between expression of p53 protein in breast cancer and axillary lymph node metastasis

Clinical Surgical Oncology Pub Date : 2024-12-01 Epub Date: 2024-11-23 DOI:10.1016/j.cson.2024.100067
Zhang Fang
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Abstract

Objective

To explore the expression of p53 protein in cancer tissue of breast cancer, analyze the relationship between positive rate of expression of p53 protein and axillary lymph node status.

Method

137 breast cancer patients in general hospital of PLA from June 2023 to October 2023 were selected and divided into axillary lymph node metastasis group and non-axillary lymph node metastasis group according to routine pathological outcome after surgery. Detect the situation of expression of p53 protein in cancer tissue using immunohistochemical method. The rate of expression of p53 protein between axillary lymph node metastasis group and non-axillary lymph node metastasis group were compared by χ2 test. At the same time, the relationship between the expression of p53 protein in breast cancer tissue and the age, the longest tumor diameter and tumor TNM stage was analyzed.

Result

The rate of expression of p53 protein was 60.78%, 43.02% in the axillary lymph node metastasis group and non-axillary lymph node metastasis group respectively. The difference was statistically significant (χ2 ​= ​4.040, P ​= ​0.044<0.05). The expression of p53 protein in breast cancer tissue was of no relationship with age (P ​= ​0.945>0.05),the longest tumor diameter (P ​= ​0.200>0.05) and tumor TNM stage (P ​= ​0.300 ​> ​0.05).

Conclusion

There was a close relationship between expression of p53 protein in breast cancer tissue and axillary lymph node metastasis, and it can be regard as a predictive factor in the axillary lymph node status.
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乳腺癌组织中p53蛋白表达与腋窝淋巴结转移的关系
目的探讨p53蛋白在乳腺癌癌组织中的表达情况,分析p53蛋白表达阳性率与腋窝淋巴结状态的关系。方法选择2023年6月至2023年10月解放军总医院收治的乳腺癌患者137例,根据术后常规病理结果分为腋窝淋巴结转移组和非腋窝淋巴结转移组。采用免疫组化方法检测癌组织中p53蛋白的表达情况。腋窝淋巴结转移组与非腋窝淋巴结转移组p53蛋白表达率比较,采用χ2检验。同时分析乳腺癌组织中p53蛋白的表达与年龄、肿瘤最长直径、肿瘤TNM分期的关系。结果p53蛋白在腋窝淋巴结转移组和非腋窝淋巴结转移组的表达率分别为60.78%和43.02%。差异有统计学意义(χ2 = 4.040, P = 0.044<0.05)。乳腺癌组织中p53蛋白的表达与年龄(P = 0.945>0.05)、肿瘤最长直径(P = 0.200>0.05)、肿瘤TNM分期(P = 0.300 >;0.05)。结论乳腺癌组织中p53蛋白表达与腋窝淋巴结转移密切相关,可作为腋窝淋巴结状态的预测因素。
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