{"title":"Associations between serum selenium and serum lipids in adolescents aged 12–19: A cross-sectional study","authors":"Huan He , Li Yang , Bailing Liu , Zhan Zhang","doi":"10.1016/j.jtemb.2024.127572","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><div>Selenium is an essential trace element in the human body and is important in lipid metabolism. Previous studies on the relationship between selenium and serum lipids were almost conducted in adults, and the research conclusions were inconsistent. Evidence linking selenium and lipids in adolescents is very limited. As an important stage of growth and development, studying the effects of trace elements on the body during adolescence is meaningful.</div></div><div><h3>Objective</h3><div>This study examined the association between serum selenium and serum lipids in adolescents aged 12–19.</div></div><div><h3>Methods</h3><div>This cross-sectional study analyzed 2209 adolescents aged 12–19 years from NHANES 2011 to 2016. Multiple linear regression analyses were performed to evaluate selenium’s association with serum lipids (containing TC, TG, LDL-C, and HDL-C). Moreover, a generalized additive model (GAM) and a fitted smoothing curve (penalized spline method) were conducted to explore the exact curve shape between them.</div></div><div><h3>Results</h3><div>In the fully adjusted model, it showed a positive association between selenium and TC, TG, LDL-C [TC (β = 0.144 (, 95 % CI (0.084, 0.204), P < 0.001), TG (β = 0.285, 95 % CI (0.134, 0.437), P < 0.001), LDL-C (β = 0.098, 95 % CI (0.022, 0.174), P = 0.011)], whereas a negative association [(β = -0.031, 95 % CI (-0.054, − 0.009), P = 0.006)] between Se and HDL-C. Subgroup analysis showed that the above associations were more significant in females aged 12–19 (P for trend < 0.05). Furthermore, linear associations were performed in Se between TC and LDL-C.</div></div><div><h3>Conclusion</h3><div>This is the first study to find evidence demonstrating associations between serum Se and serum lipids in adolescents aged 12–19. The validation of our findings will require further research.</div></div>","PeriodicalId":49970,"journal":{"name":"Journal of Trace Elements in Medicine and Biology","volume":"87 ","pages":"Article 127572"},"PeriodicalIF":3.6000,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Trace Elements in Medicine and Biology","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0946672X24001925","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Background
Selenium is an essential trace element in the human body and is important in lipid metabolism. Previous studies on the relationship between selenium and serum lipids were almost conducted in adults, and the research conclusions were inconsistent. Evidence linking selenium and lipids in adolescents is very limited. As an important stage of growth and development, studying the effects of trace elements on the body during adolescence is meaningful.
Objective
This study examined the association between serum selenium and serum lipids in adolescents aged 12–19.
Methods
This cross-sectional study analyzed 2209 adolescents aged 12–19 years from NHANES 2011 to 2016. Multiple linear regression analyses were performed to evaluate selenium’s association with serum lipids (containing TC, TG, LDL-C, and HDL-C). Moreover, a generalized additive model (GAM) and a fitted smoothing curve (penalized spline method) were conducted to explore the exact curve shape between them.
Results
In the fully adjusted model, it showed a positive association between selenium and TC, TG, LDL-C [TC (β = 0.144 (, 95 % CI (0.084, 0.204), P < 0.001), TG (β = 0.285, 95 % CI (0.134, 0.437), P < 0.001), LDL-C (β = 0.098, 95 % CI (0.022, 0.174), P = 0.011)], whereas a negative association [(β = -0.031, 95 % CI (-0.054, − 0.009), P = 0.006)] between Se and HDL-C. Subgroup analysis showed that the above associations were more significant in females aged 12–19 (P for trend < 0.05). Furthermore, linear associations were performed in Se between TC and LDL-C.
Conclusion
This is the first study to find evidence demonstrating associations between serum Se and serum lipids in adolescents aged 12–19. The validation of our findings will require further research.
期刊介绍:
The journal provides the reader with a thorough description of theoretical and applied aspects of trace elements in medicine and biology and is devoted to the advancement of scientific knowledge about trace elements and trace element species. Trace elements play essential roles in the maintenance of physiological processes. During the last decades there has been a great deal of scientific investigation about the function and binding of trace elements. The Journal of Trace Elements in Medicine and Biology focuses on the description and dissemination of scientific results concerning the role of trace elements with respect to their mode of action in health and disease and nutritional importance. Progress in the knowledge of the biological role of trace elements depends, however, on advances in trace elements chemistry. Thus the Journal of Trace Elements in Medicine and Biology will include only those papers that base their results on proven analytical methods.
Also, we only publish those articles in which the quality assurance regarding the execution of experiments and achievement of results is guaranteed.