Arterial calcification in the heart–brain axis and cognitive performance over time

IF 11.1 1区医学 Q1 CLINICAL NEUROLOGY Alzheimer's & Dementia Pub Date : 2024-12-03 DOI:10.1002/alz.14374

Anna M. Streiber, Tim C. van den Beukel, Ilse vom Hofe, Julia Neitzel, Meike W. Vernooij, Daniel Bos, Elisabeth J. Vinke

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Abstract

BACKGROUND

While cross-sectional studies suggest a link between arteriosclerosis and cognition, longitudinal research is lacking. We investigated how arteriosclerosis in the heart–brain axis is related to cognitive performance trajectories over time.

METHODS

Within the population-based Rotterdam Study, 2368 participants underwent noncontrast CT to quantify arterial calcification, a hallmark of arteriosclerosis, in five major arteries in the heart–brain axis. Following this scan, participants underwent repeated cognitive testing. The association between baseline calcification and longitudinal cognitive test performance was investigated using mixed models.

RESULTS

Higher calcification was associated with worse baseline cognitive performance across domains (e.g., β for global cognition per 10-percentile increase of intracranial carotid artery calcification: −0.01 [95% confidence interval (CI): −0.03, −0.00]). Cognition declined faster across all cognitive tests, specifically for the intracranial carotid artery (p ≤ 0.001).

DISCUSSION

Arterial calcification is associated with accelerated cognitive decline across domains, especially for arteries closer to the brain. This effect may be attributable to hemodynamic changes preceding neurovascular damage.

Highlights

Arterial calcification is related to accelerated cognitive decline.
Arterial calcification closer to the brain exerts the most influence on cognitive decline.
Vascular damage influences cognitive decline across various domains.

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心脑轴动脉钙化与认知能力随时间的变化

虽然横断面研究表明动脉硬化和认知之间存在联系，但缺乏纵向研究。随着时间的推移，我们研究了心脑轴动脉硬化与认知表现轨迹的关系。

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来源期刊

Alzheimer's & Dementia 医学-临床神经学

CiteScore

14.50

自引率

5.00%

发文量

299

审稿时长

3 months

期刊介绍： Alzheimer's & Dementia is a peer-reviewed journal that aims to bridge knowledge gaps in dementia research by covering the entire spectrum, from basic science to clinical trials to social and behavioral investigations. It provides a platform for rapid communication of new findings and ideas, optimal translation of research into practical applications, increasing knowledge across diverse disciplines for early detection, diagnosis, and intervention, and identifying promising new research directions. In July 2008, Alzheimer's & Dementia was accepted for indexing by MEDLINE, recognizing its scientific merit and contribution to Alzheimer's research.