Lactate gives a sour taste

IF 60.7 1区医学 Q1 ONCOLOGY Nature Reviews Cancer Pub Date : 2024-12-03 DOI:10.1038/s41568-024-00783-7

Daniela Senft

引用次数: 0

Abstract

Wang et al. demonstrate that lactate derived from glioblastoma stem cells, microglia and macrophages drives histone lactylation, activating immunosuppressive transcriptional programs and upregulating CD47, to suppress phagocytosis.

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乳酸盐有酸味

Wang等人证明来自胶质母细胞瘤干细胞、小胶质细胞和巨噬细胞的乳酸驱动组蛋白乳酸化，激活免疫抑制转录程序并上调CD47，从而抑制吞噬。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature Reviews Cancer 医学-肿瘤学

CiteScore

111.90

自引率

0.40%

发文量

审稿时长

6-12 weeks

期刊介绍： Nature Reviews Cancer, a part of the Nature Reviews portfolio of journals, aims to be the premier source of reviews and commentaries for the scientific communities it serves. The correct abbreviation for abstracting and indexing purposes is Nat. Rev. Cancer. The international standard serial numbers (ISSN) for Nature Reviews Cancer are 1474-175X (print) and 1474-1768 (online). Unlike other journals, Nature Reviews Cancer does not have an external editorial board. Instead, all editorial decisions are made by a team of full-time professional editors who are PhD-level scientists. The journal publishes Research Highlights, Comments, Reviews, and Perspectives relevant to cancer researchers, ensuring that the articles reach the widest possible audience due to their broad scope.

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