Intermittent fasting for weight management and metabolic health: An updated comprehensive umbrella review of health outcomes.

IF 5.4 2区医学 Q1 ENDOCRINOLOGY & METABOLISM Diabetes, Obesity & Metabolism Pub Date : 2025-02-01 Epub Date: 2024-12-01 DOI:10.1111/dom.16092

Zixin Hua, Siyu Yang, Jiqian Li, Yiqi Sun, Yin Liao, Siyang Song, Sheng Cheng, Zhe Li, Ze Li, Dandan Li, Heng Guo, Hongge Yang, Yingming Zheng, Xingang Li

{"title":"Intermittent fasting for weight management and metabolic health: An updated comprehensive umbrella review of health outcomes.","authors":"Zixin Hua, Siyu Yang, Jiqian Li, Yiqi Sun, Yin Liao, Siyang Song, Sheng Cheng, Zhe Li, Ze Li, Dandan Li, Heng Guo, Hongge Yang, Yingming Zheng, Xingang Li","doi":"10.1111/dom.16092","DOIUrl":null,"url":null,"abstract":"Aims: To provide an updated comprehensive evaluation of the quality and evidence association of existing studies on health outcomes related to intermittent fasting (IF).Materials and methods: We conducted a systematic search of PubMed, Web of Science, Cochrane Library, and Embase databases, covering literature up to June 2024. Meta-analyses and systematic reviews that include adult populations and quantitatively analyse health outcomes related to IF interventional studies are included. For evidence with complete data, we reanalyzed health evidence effect sizes and 95% confidence intervals using random-effects models. Article quality and the certainty of the evidence were graded using A Measurement Tool to Assess Systematic Reviews (AMSTAR-2), Grading of Recommendations Assessment, Development and Evaluation (GRADE) system, and a standardized credibility grading system.Results: Twelve meta-analysis studies and 122 health outcome associations with IF were identified. High-quality evidence indicated significant associations between time-restricted eating (TRE) and weight loss, fat mass reduction, decreased fasting insulin and glycosylated haemoglobin levels in overweight or obese adults, as well as between the 5:2 diet and reduced low-density lipoprotein cholesterol levels. Moderate-to-low-quality evidence suggested associations between modified alternate-day fasting and improvements in body weight, lipid profile and blood pressure. Additionally, high-to-low-quality evidence showed that IF regimens effectively improved liver health in non-alcoholic fatty liver disease.Conclusions: This umbrella review highlights IF, especially TRE, as a promising intervention for weight and metabolic health, particularly beneficial for overweight or obese adults. We also highlight the need for further extensive research to understand the long-term effects, individualized IF plans and potential adverse effects of IF in different populations.","PeriodicalId":158,"journal":{"name":"Diabetes, Obesity & Metabolism","volume":" ","pages":"920-932"},"PeriodicalIF":5.4000,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Diabetes, Obesity & Metabolism","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1111/dom.16092","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/12/1 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}

引用次数: 0

Abstract

Aims: To provide an updated comprehensive evaluation of the quality and evidence association of existing studies on health outcomes related to intermittent fasting (IF).

Materials and methods: We conducted a systematic search of PubMed, Web of Science, Cochrane Library, and Embase databases, covering literature up to June 2024. Meta-analyses and systematic reviews that include adult populations and quantitatively analyse health outcomes related to IF interventional studies are included. For evidence with complete data, we reanalyzed health evidence effect sizes and 95% confidence intervals using random-effects models. Article quality and the certainty of the evidence were graded using A Measurement Tool to Assess Systematic Reviews (AMSTAR-2), Grading of Recommendations Assessment, Development and Evaluation (GRADE) system, and a standardized credibility grading system.

Results: Twelve meta-analysis studies and 122 health outcome associations with IF were identified. High-quality evidence indicated significant associations between time-restricted eating (TRE) and weight loss, fat mass reduction, decreased fasting insulin and glycosylated haemoglobin levels in overweight or obese adults, as well as between the 5:2 diet and reduced low-density lipoprotein cholesterol levels. Moderate-to-low-quality evidence suggested associations between modified alternate-day fasting and improvements in body weight, lipid profile and blood pressure. Additionally, high-to-low-quality evidence showed that IF regimens effectively improved liver health in non-alcoholic fatty liver disease.

Conclusions: This umbrella review highlights IF, especially TRE, as a promising intervention for weight and metabolic health, particularly beneficial for overweight or obese adults. We also highlight the need for further extensive research to understand the long-term effects, individualized IF plans and potential adverse effects of IF in different populations.

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

间歇性禁食对体重管理和代谢健康的影响：对健康结果的最新综合综述

目的：对间歇性禁食（IF）相关健康结局的现有研究的质量和证据关联进行最新的综合评价。材料和方法：系统检索PubMed、Web of Science、Cochrane Library和Embase数据库，检索截止到2024年6月的文献。纳入纳入成人人群的荟萃分析和系统评价，并定量分析与IF介入性研究相关的健康结果。对于数据完整的证据，我们使用随机效应模型重新分析了健康证据的效应大小和95%置信区间。文章质量和证据的确定性采用评估系统评价的测量工具（AMSTAR-2）、建议评估、发展和评价评分（GRADE）系统和标准化可信度评分系统进行评分。结果：确定了12项荟萃分析研究和122项与IF相关的健康结局。高质量的证据表明，限时饮食（TRE）与体重减轻、脂肪减少、超重或肥胖成年人空腹胰岛素和糖化血红蛋白水平降低以及5:2饮食与低密度脂蛋白胆固醇水平降低之间存在显著关联。中低质量证据表明，改进隔日禁食与改善体重、血脂和血压之间存在关联。此外，高到低质量的证据表明，干扰素方案有效地改善了非酒精性脂肪性肝病患者的肝脏健康。结论：本综述强调了IF，特别是TRE，作为一种有希望的体重和代谢健康干预措施，对超重或肥胖的成年人尤其有益。我们还强调需要进一步进行广泛的研究，以了解干扰素在不同人群中的长期影响、个体化干扰素计划和潜在的不良影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Diabetes, Obesity & Metabolism 医学-内分泌学与代谢

CiteScore

10.90

自引率

6.90%

发文量

319

审稿时长

3-8 weeks

期刊介绍： Diabetes, Obesity and Metabolism is primarily a journal of clinical and experimental pharmacology and therapeutics covering the interrelated areas of diabetes, obesity and metabolism. The journal prioritises high-quality original research that reports on the effects of new or existing therapies, including dietary, exercise and lifestyle (non-pharmacological) interventions, in any aspect of metabolic and endocrine disease, either in humans or animal and cellular systems. ‘Metabolism’ may relate to lipids, bone and drug metabolism, or broader aspects of endocrine dysfunction. Preclinical pharmacology, pharmacokinetic studies, meta-analyses and those addressing drug safety and tolerability are also highly suitable for publication in this journal. Original research may be published as a main paper or as a research letter.