Correlation of Circulating Complement Levels with Clinical Characteristics of Patients with Diabetic Retinopathy.

IF 2.1 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL International Journal of General Medicine Pub Date : 2024-11-26 eCollection Date: 2024-01-01 DOI:10.2147/IJGM.S483571
Guangjiang Wang, Yuan Guo
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引用次数: 0

Abstract

Background: Type 2 diabetes mellitus (T2DM) is associated with diabetic retinopathy (DR). The complement system maintains the normal physiologic microenvironment of the retina. The relationship between serum complement levels and clinical features of DR remains unclear.

Methods: Clinical characteristics of 252 patients with T2DM including 101 with non-DR (NDR), 79 with nonproliferative DR (NPDR), and 72 with proliferative DR (PDR) were prospectively analyzed. Serum complement levels were compared between NDR and DR patients. The correlation between clinical characteristics and complement levels in DR patients was analyzed. A multifactorial logistic analysis was constructed to predict the risk of developing DR in T2DM.

Results: Serum C4, CFB, CFI, C3 and C5 levels were higher in DR patients than in NDR patients (all P < 0.05). In T2DM patients, C3 and C4 levels were higher in PDR patients than in DR patients (all P < 0.05), and MBL levels were not statistically different between the two cohorts (P > 0.05). These complement components or fragments were positively correlated with the duration of diabetes, glycosylated hemoglobin (HbA1c), and triglycerides (TG) (all P < 0.05). C3, C5, the duration of diabetes, HbA1c, and TG were the independent risk factors for DR in T2DM patients. The ROC model showed good value for predicting the risk of developing DR in T2DM with an area under the curve of 0.887.

Conclusion: Serum complements C3 and C5 are predictive factors for DR in patients with T2DM. The prediction model constructed by the clinical characteristics of patients with T2DM and complement can better distinguish between NDR and DR, and can be used as a potential biomarker for assessing the risk of developing DR.

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International Journal of General Medicine
International Journal of General Medicine Medicine-General Medicine
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1113
审稿时长
16 weeks
期刊介绍: The International Journal of General Medicine is an international, peer-reviewed, open access journal that focuses on general and internal medicine, pathogenesis, epidemiology, diagnosis, monitoring and treatment protocols. The journal is characterized by the rapid reporting of reviews, original research and clinical studies across all disease areas. A key focus of the journal is the elucidation of disease processes and management protocols resulting in improved outcomes for the patient. Patient perspectives such as satisfaction, quality of life, health literacy and communication and their role in developing new healthcare programs and optimizing clinical outcomes are major areas of interest for the journal. As of 1st April 2019, the International Journal of General Medicine will no longer consider meta-analyses for publication.
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