Fibrinogen, FDP and D-Dimer as Potential Biomarkers for Disease Severity in Ulcerative Colitis: A Retrospective Study.

IF 2 4区医学 Q2 MEDICINE, GENERAL & INTERNAL International Journal of General Medicine Pub Date : 2024-11-26 eCollection Date: 2024-01-01 DOI:10.2147/IJGM.S477285

Wan Feng, Lei Zhu, Song Zhao, Kai Zheng, Luzhou Xu, Hong Shen

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Abstract

Purpose: Ulcerative colitis (UC) is an idiopathic, chronic inflammatory disease that primarily affects the large intestine. Coagulation abnormalities have been detected in UC patients. This study aimed to evaluate coagulation-related parameters in patients with UC.

Patients and methods: A total of 364 UC patients were analyzed with 163 female and 201 male. Disease activity was determined according to the Truelove and Witts criteria. The fibrinogen (FIB), D-dimer, fibrin/fibrinogen degradation products (FDP), C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) levels were evaluated.

Results: We found higher D-dimer, FDP, FIB levels in severe UC compared with non-severe patients.The area under the curve (AUC) of D-dimer was 0.852 (95% CI 0.805 to 0.898) and the optimum cut-off point was 0.585, with a sensitivity of 80.6% and a specificity of 78.9%. Furthermore, D-dimer and FIB are positively correlated with ESR and CRP levels.

Conclusion: Our results indicate that D-dimer, FDP, and FIB levels are potential biomarkers for disease severity in UC patients.

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纤维蛋白原，FDP和d -二聚体作为溃疡性结肠炎疾病严重程度的潜在生物标志物：一项回顾性研究

目的：溃疡性结肠炎（UC）是一种特发性慢性炎症性疾病，主要影响大肠。在UC患者中发现了凝血异常。本研究旨在评估UC患者的凝血相关参数。患者和方法：共分析364例UC患者，其中女性163例，男性201例。根据Truelove和Witts标准确定疾病活动性。评估纤维蛋白原（FIB）、d -二聚体、纤维蛋白/纤维蛋白原降解产物（FDP）、c反应蛋白（CRP）和红细胞沉降率（ESR）水平。结果：我们发现重症UC患者的d -二聚体、FDP、FIB水平高于非重症UC患者。d -二聚体的曲线下面积（AUC）为0.852 (95% CI 0.805 ~ 0.898)，最佳分界点为0.585，灵敏度为80.6%，特异性为78.9%。此外，d -二聚体和FIB与ESR和CRP水平呈正相关。结论：我们的研究结果表明，d -二聚体、FDP和FIB水平是UC患者疾病严重程度的潜在生物标志物。

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来源期刊

International Journal of General Medicine Medicine-General Medicine

自引率

0.00%

发文量

1113

审稿时长

16 weeks

期刊介绍： The International Journal of General Medicine is an international, peer-reviewed, open access journal that focuses on general and internal medicine, pathogenesis, epidemiology, diagnosis, monitoring and treatment protocols. The journal is characterized by the rapid reporting of reviews, original research and clinical studies across all disease areas. A key focus of the journal is the elucidation of disease processes and management protocols resulting in improved outcomes for the patient. Patient perspectives such as satisfaction, quality of life, health literacy and communication and their role in developing new healthcare programs and optimizing clinical outcomes are major areas of interest for the journal. As of 1st April 2019, the International Journal of General Medicine will no longer consider meta-analyses for publication.