Increased Wound Prevalence in those Exposed to Xylazine and Fentanyl Compared to Those Exposed to Fentanyl: An Observational Study.

IF 4.2 3区医学 Q1 SUBSTANCE ABUSE Journal of Addiction Medicine Pub Date : 2024-12-03 DOI:10.1097/ADM.0000000000001429

Carolanne E Semancik

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Abstract

Objectives: The aim of this study is to determine the difference, if any, in prevalence of wounds in individuals who were exposed to xylazine and fentanyl compared to individuals who were exposed to fentanyl and not xylazine.

Methods: A large inpatient substance use disorder specialty hospital provided medical records over an 8-month period from July 2023 to February 2024. Individuals were admitted to an American Society of Addiction Medicine 3.7 level of care where a urine drug screen and skin assessment was conducted on admission. If the urine screen noted a presence of fentanyl, the sample was then tested for xylazine exposure. Patients were considered positive for wounds on admission to treatment if any wound was noted during the skin assessment during the admission process.

Results: A total of 282 medical records were identified. A chi square test of association was completed and revealed a statistically significant association between xylazine exposure and wounds (P = 0.002, odds ratio = 2.420, 95% confidence interval = 1.376-4.254).

Conclusions: This study provides early support for the previously theorized connection between xylazine exposure and wounds.

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与芬太尼暴露者相比，暴露于噻嗪和芬太尼的患者伤口患病率增加：一项观察性研究。

目的：本研究的目的是确定暴露于噻嗪和芬太尼的个体与暴露于芬太尼而非噻嗪的个体在伤口发生率方面的差异（如果有的话）。方法：某大型住院患者物质使用障碍专科医院提供2023年7月至2024年2月8个月的医疗记录。这些人被纳入美国成瘾医学协会的3.7级护理，在入院时进行尿液药物筛查和皮肤评估。如果尿液筛查发现芬太尼的存在，则对样本进行二甲肼暴露测试。如果在入院过程中皮肤评估中发现任何伤口，则认为患者入院治疗时伤口呈阳性。结果：共鉴定出282份病案。经卡方相关性检验，发现噻嗪暴露与伤口有统计学意义（P = 0.002，优势比= 2.420,95%可信区间= 1.376 ~ 4.254）。结论：本研究为先前的理论理论在二甲肼暴露和伤口之间的联系提供了早期支持。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Addiction Medicine 医学-药物滥用

CiteScore

6.10

自引率

9.10%

发文量

260

审稿时长

>12 weeks

期刊介绍： The mission of Journal of Addiction Medicine, the official peer-reviewed journal of the American Society of Addiction Medicine, is to promote excellence in the practice of addiction medicine and in clinical research as well as to support Addiction Medicine as a mainstream medical sub-specialty. Under the guidance of an esteemed Editorial Board, peer-reviewed articles published in the Journal focus on developments in addiction medicine as well as on treatment innovations and ethical, economic, forensic, and social topics including: •addiction and substance use in pregnancy •adolescent addiction and at-risk use •the drug-exposed neonate •pharmacology •all psychoactive substances relevant to addiction, including alcohol, nicotine, caffeine, marijuana, opioids, stimulants and other prescription and illicit substances •diagnosis •neuroimaging techniques •treatment of special populations •treatment, early intervention and prevention of alcohol and drug use disorders •methodological issues in addiction research •pain and addiction, prescription drug use disorder •co-occurring addiction, medical and psychiatric disorders •pathological gambling disorder, sexual and other behavioral addictions •pathophysiology of addiction •behavioral and pharmacological treatments •issues in graduate medical education •recovery •health services delivery •ethical, legal and liability issues in addiction medicine practice •drug testing •self- and mutual-help.