Increase in Blood Eosinophil Count Over Time and Sputum IL8 are Associated with FEV1 Decline in Asthma.

IF 4.6 2区 医学 Q1 RESPIRATORY SYSTEM Lung Pub Date : 2024-11-30 DOI:10.1007/s00408-024-00760-9
S Graff, C Moermans, S Gerday, M Henket, V Paulus, F Guissard, R Louis, F Schleich
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Abstract

Background: Asthma is associated with accelerated rate of FEV1 decline.

Objective: To determine predictive factors associated with accelerated FEV1 decline in adult asthma and evaluate sputum cytokines as potential biomarkers for airflow decline.

Methods: We recruited 125 asthmatics evaluated at the asthma clinic of Liège and reevaluated them at least 5 years later. Clinical, functional and inflammatory characteristics were compared between patients with accelerated decline (FEV1 decline > 0.85% pred.y-1) and others. Predictive factors were highlighted with linear regression analysis. Sputum EGF, VEGF, FGF, IL5, IL8, TGF-β, and IgE levels were measured in 58 of these patients at both visits by Human XL cytokine Luminex Performance assay and Elisa.

Results: Post-BD FEV1 decline was 0.06 ± 2.44% pred.y-1 in the overall population. Median (IQR) time between visits was 66 (62 - 86) months. The multivariable analysis showed that an increase in blood eosinophils over time (Δ BEC) (Reg. Coef. (95%CI): 0.002 (0.001 to 0.004), p = 0.005)) and onset of asthma (0.04 (0.003 to 0.07), p = 0.036) were independently associated with FEV1 decline. IL8 levels measured at baseline were higher (499 (408-603) pg/ml, p = 0.0040) in patients with accelerated decline compared to others (143 (88-308) pg/ml).

Conclusion: In this study, we have confirmed that an increase in blood eosinophil counts over a follow-up of at least 5 years and later onset of asthma are associated with accelerated annual FEV1 decline. Moreover, high sputum IL8 levels could be a risk factor for accelerated decline in asthma patients.

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随着时间的推移,血嗜酸性粒细胞计数和痰il - 8的增加与哮喘患者FEV1下降有关。
背景:哮喘与FEV1下降速度加快有关。目的:确定与成人哮喘患者FEV1加速下降相关的预测因素,并评估痰细胞因子作为气流下降的潜在生物标志物。方法:我们招募125例在li我院哮喘门诊评估的哮喘患者,并在至少5年后对他们进行重新评估。比较加速下降组(FEV1下降> 0.85% pred.y-1)与其他组患者的临床、功能和炎症特征。用线性回归分析突出预测因素。采用Human XL细胞因子Luminex性能测定法和Elisa法测定58例患者两次就诊时痰中EGF、VEGF、FGF、IL5、IL8、TGF-β和IgE水平。结果:bd后FEV1下降0.06±2.44%。总体Y-1。就诊间隔中位(IQR)时间为66(62 - 86)个月。多变量分析显示,随着时间的推移,血液嗜酸性粒细胞增加(Δ BEC) (Reg。系数。(95%CI): 0.002 (0.001 ~ 0.004), p = 0.005)和哮喘发作(0.04 (0.003 ~ 0.07),p = 0.036)与FEV1下降独立相关。基线时测量的il - 8水平在加速下降的患者中高于其他患者(143 (88-308)pg/ml) (499 (408-603) pg/ml, p = 0.0040)。结论:在这项研究中,我们已经证实,在至少5年的随访中,血液嗜酸性粒细胞计数的增加和哮喘发病晚与每年FEV1的加速下降有关。此外,高痰il - 8水平可能是哮喘患者病情加速下降的一个危险因素。
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来源期刊
Lung
Lung 医学-呼吸系统
CiteScore
9.10
自引率
10.00%
发文量
95
审稿时长
6-12 weeks
期刊介绍: Lung publishes original articles, reviews and editorials on all aspects of the healthy and diseased lungs, of the airways, and of breathing. Epidemiological, clinical, pathophysiological, biochemical, and pharmacological studies fall within the scope of the journal. Case reports, short communications and technical notes can be accepted if they are of particular interest.
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