Neurophysiological Features of Tremor during Walking in Parkinson's Disease.

IF 2.6 4区医学 Q2 CLINICAL NEUROLOGY Movement Disorders Clinical Practice Pub Date : 2024-12-03 DOI:10.1002/mdc3.14293

Matteo Costanzo, Francesco Marchet, Giorgio Leodori, Carolina Cutrona, Maria Ilenia De Bartolo, Giorgio Vivacqua, Antonella Conte, Giovanni Fabbrini, Alfredo Berardelli, Daniele Belvisi

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Abstract

Background: In Parkinson's Disease (PD), upper limb tremor during walking (TW) is observed and clinical observations suggest it may represent a variant of rest tremor. However, its neurophysiological characteristics remain unexplored.

Objectives: This study compared the neurophysiological features of TW with other PD tremors and tested whether TW arises from reduced ipsilateral arm swing.

Methods: Inertial measurement units were used to measure frequency and amplitude of tremors and arm swing during walking in 25 PD patients.

Results: TW shared a similar frequency with rest and re-emergent tremor (RET) but showed significantly greater amplitude. A positive correlation was observed between the amplitude and frequency of TW with those of rest and RET on the same side. TW distribution was unrelated to reduced arm swing during walking, suggesting TW is not due to decreased ipsilateral arm movement.

Conclusions: These findings suggest that walking may act as a provocation maneuver, triggering rest tremor.

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来源期刊

Movement Disorders Clinical Practice CLINICAL NEUROLOGY-

CiteScore

4.00

自引率

7.50%

发文量

218

期刊介绍： Movement Disorders Clinical Practice- is an online-only journal committed to publishing high quality peer reviewed articles related to clinical aspects of movement disorders which broadly include phenomenology (interesting case/case series/rarities), investigative (for e.g- genetics, imaging), translational (phenotype-genotype or other) and treatment aspects (clinical guidelines, diagnostic and treatment algorithms)