Hopkins Syndrome: An Uncommon Cause of Weakness in Intensive Care Unit.

IF 3.2 3区医学 Q2 CLINICAL NEUROLOGY Pediatric neurology Pub Date : 2025-02-01 Epub Date: 2024-11-14 DOI:10.1016/j.pediatrneurol.2024.11.006

Trajano Aguiar Pires Gonçalves, Maria Clara Zanon Zotin, Carolina Lavigne Moreira, Rodrigo Siqueira Soares Frezatti, Antonio Carlos Santos, Wilson Marques Junior, Pedro José Tomaselli

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Abstract

Background: Hopkins syndrome is a rare polio-like syndrome, with an incompletely understood pathophysiology, that affects children after asthma crisis.

Methods: A 10-year-old girl was admitted to the intensive care unit following a severe asthma attack, requiring mechanical ventilation for a period of five days. After regaining consciousness, the patient exhibited development of asymmetric flaccid paraparesis. Neuroaxis magnetic resonance imaging revealed contrast enhancement in the anterior lumbar roots, with the enhancement originating at the T11 level and extending downward on axial series. Nerve conduction study revealed the absence of compound muscle action potentials in the tibialis and peroneal nerves on the left, with preserved sensory nerve action potentials.

Results: Based on the patient's clinical phenotype, which was most consistent with a polio-like syndrome arising acutely following an asthmatic crisis, the diagnosis of Hopkins syndrome was established.

Conclusion: Hopkins syndrome is a rare polio-like syndrome that is probably underdiagnosed and has a poor motor prognosis.

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霍普金斯综合征：重症监护病房虚弱的罕见原因。

背景：霍普金斯综合征是一种罕见的脊髓灰质炎样综合征，其病理生理学尚不完全清楚，影响哮喘危象后的儿童。方法：一名10岁女孩在严重哮喘发作后住进重症监护室，需要机械通气5天。恢复意识后，患者出现不对称弛缓性截瘫。神经轴磁共振成像显示腰椎前根增强，增强始于T11水平，沿轴向线向下延伸。神经传导研究显示左侧胫腓神经复合肌动作电位缺失，感觉神经动作电位保留。结果：根据患者的临床表型，其与哮喘危象后急性出现的脊髓灰质炎样综合征最一致，建立了霍普金斯综合征的诊断。结论：霍普金斯综合征是一种罕见的脊髓灰质炎样综合征，可能诊断不足，运动预后较差。

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来源期刊

Pediatric neurology 医学-临床神经学

CiteScore

4.80

自引率

2.60%

发文量

176

审稿时长

78 days

期刊介绍： Pediatric Neurology publishes timely peer-reviewed clinical and research articles covering all aspects of the developing nervous system. Pediatric Neurology features up-to-the-minute publication of the latest advances in the diagnosis, management, and treatment of pediatric neurologic disorders. The journal''s editor, E. Steve Roach, in conjunction with the team of Associate Editors, heads an internationally recognized editorial board, ensuring the most authoritative and extensive coverage of the field. Among the topics covered are: epilepsy, mitochondrial diseases, congenital malformations, chromosomopathies, peripheral neuropathies, perinatal and childhood stroke, cerebral palsy, as well as other diseases affecting the developing nervous system.