Association of serum ferritin with total and regional fat measured by dual-energy X-ray absorptiometry in a nationally representative survey.

IF 3.9 3区医学 Q2 ENDOCRINOLOGY & METABOLISM Obesity Facts Pub Date : 2024-12-03 DOI:10.1159/000542896

Yuan Chen, Chao Wang, Yanyan Xiao, Tian Hu, Xuerong Yang, Guohua Mu, Hao Lu, Junfei Xu, Chi Chen

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Abstract

Introduction: Fat distribution is a stronger predictor for cardiometabolic morbidity and mortality. We aimed to investigate the association of elevated iron stores, measured as serum ferritin levels, with total and regional body fat.

Methods: Data from 2,646 adults from the National Health and Nutrition Examination Survey 2017-2018 was analyzed. Dual-energy X-ray absorptiometry was used to measure overall and regional body fat. The fat mass index (FMI) was calculated by dividing the fat mass (kg) by the square of body height (m²). The leg fat mass to trunk fat mass ratio (LTR) was used to assess the relative distribution of leg fat compared to trunk fat.

Results: Medians (IQR) of serum ferritin levels were 0.168 μg/mL (0.104-0.269) for men and 0.053 μg/mL (0.026-0.102) for women. After adjusting for sociodemographic, lifestyle, and metabolic factors, serum ferritin showed a significant positive association with total FMI (β=2.662) and trunk FMI (β=0.983), and a negative association with leg FMI (β=-0.324) and LTR (β=-0.160) in men. In women, serum ferritin showed a significant positive association with total FMI (β=4.658), trunk FMI (β=2.085), and negative association with LTR (β=-0.312). Significant positive trends were observed for serum ferritin with total and trunk FMI in men and women, using the lowest serum ferritin quartile as the reference group. Additionally, significant negative trends were observed for serum ferritin with leg FMI and LTR in men. The mediation analysis revealed that C-reactive protein mediated 16.4% and 22.6% of the potential effects of serum ferritin on trunk FMI in men and women, respectively.

Conclusion: Higher ferritin levels were associated with greater total and trunk fat but lower leg fat. Further prospective and mechanistic studies are warranted to confirm the study results.

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在一项具有全国代表性的调查中，用双能x线吸收仪测量血清铁蛋白与总脂肪和局部脂肪的关系。

简介：脂肪分布是心脏代谢发病率和死亡率的一个较强的预测因子。我们的目的是研究血清铁蛋白水平升高与总体脂和局部体脂之间的关系。方法：分析2017-2018年全国健康与营养检查调查中2646名成年人的数据。采用双能x线吸收仪测量全身和局部体脂。脂肪质量指数（FMI）的计算方法为脂肪质量（kg）除以身高（m²）的平方。用腿部脂肪质量与躯干脂肪质量比（LTR）来评价腿部脂肪与躯干脂肪的相对分布。结果：血清铁蛋白水平中位数（IQR）男性为0.168 μg/mL(0.104 ~ 0.269)，女性为0.053 μg/mL（0.026 ~ 0.102）。在调整了社会人口统计学、生活方式和代谢因素后，血清铁蛋白与男性总FMI （β=2.662）和躯干FMI （β=0.983）呈显著正相关，与腿部FMI （β=-0.324）和LTR （β=-0.160）呈负相关。在女性中，血清铁蛋白与总FMI （β=4.658）、躯干FMI （β=2.085）呈正相关，与LTR呈负相关（β=-0.312）。以最低的血清铁蛋白四分位数作为参照组，在男性和女性的总和主干FMI中观察到血清铁蛋白的显著阳性趋势。此外，血清铁蛋白与男性腿部FMI和LTR呈显著负相关趋势。中介分析显示，c反应蛋白分别介导了16.4%和22.6%的血清铁蛋白对男性和女性躯干FMI的潜在影响。结论：较高的铁蛋白水平与较高的总脂肪和躯干脂肪有关，而与小腿脂肪有关。需要进一步的前瞻性和机制研究来证实研究结果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Obesity Facts 医学-内分泌学与代谢

CiteScore

6.80

自引率

5.60%

发文量

审稿时长

6-12 weeks

期刊介绍： ''Obesity Facts'' publishes articles covering all aspects of obesity, in particular epidemiology, etiology and pathogenesis, treatment, and the prevention of adiposity. As obesity is related to many disease processes, the journal is also dedicated to all topics pertaining to comorbidity and covers psychological and sociocultural aspects as well as influences of nutrition and exercise on body weight. The editors carefully select papers to present only the most recent findings in clinical practice and research. All professionals concerned with obesity issues will find this journal a most valuable update to keep them abreast of the latest scientific developments.