Circulating Chromogranin A is associated with disease extent, progression and recurrence in patients with non-functioning pancreatic neuroendocrine tumor (NF-PNET).

IF 1.7 4区 医学 Q3 GASTROENTEROLOGY & HEPATOLOGY Pancreas Pub Date : 2024-11-29 DOI:10.1097/MPA.0000000000002428
Nicholas J Zyromski, Kyle A Lewellen, Thomas K Maatman, Sean P McGuire
{"title":"Circulating Chromogranin A is associated with disease extent, progression and recurrence in patients with non-functioning pancreatic neuroendocrine tumor (NF-PNET).","authors":"Nicholas J Zyromski, Kyle A Lewellen, Thomas K Maatman, Sean P McGuire","doi":"10.1097/MPA.0000000000002428","DOIUrl":null,"url":null,"abstract":"<p><strong>Objectives: </strong>Non-functioning Pancreatic Neuroendocrine Tumors (NF-PNET) are rare tumors with heterogeneous biology. Radiology and serum biomarkers are used for post-resection surveillance; however, no universally established protocol exists. Serum Chromogranin A (CgA) concentration is elevated in NF-PNET, and generally correlates with burden of disease; many CgA studies include mixed gastrointestinal and pancreatic populations. We sought to review the NF-PNET literature with focus on post-resection surveillance and hypothesized that CgA is useful for surveillance after NF-PNET resection.</p><p><strong>Methods: </strong>Comprehensive English literature review by PICO criteria (P-human NF-PNET patients; I-pancreatectomy; C- none; O- CgA correlation with disease recurrence).</p><p><strong>Results: </strong>Four studies yielded granular data for resected NF-PNET patients. From 333 patients, 113 recurred and 110 (97%) had elevated CgA. Additional 7 studies with mixed gastro-entero-pancreatic NET included 269 NF-PNET patients. In these patients, CgA uniformly predicted disease extent.</p><p><strong>Conclusions: </strong>Serum Chromogranin A correlates with disease extent in NF-PNET, and is useful for surveillance after resection of NF-PNET.</p>","PeriodicalId":19733,"journal":{"name":"Pancreas","volume":" ","pages":""},"PeriodicalIF":1.7000,"publicationDate":"2024-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Pancreas","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1097/MPA.0000000000002428","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"GASTROENTEROLOGY & HEPATOLOGY","Score":null,"Total":0}
引用次数: 0

Abstract

Objectives: Non-functioning Pancreatic Neuroendocrine Tumors (NF-PNET) are rare tumors with heterogeneous biology. Radiology and serum biomarkers are used for post-resection surveillance; however, no universally established protocol exists. Serum Chromogranin A (CgA) concentration is elevated in NF-PNET, and generally correlates with burden of disease; many CgA studies include mixed gastrointestinal and pancreatic populations. We sought to review the NF-PNET literature with focus on post-resection surveillance and hypothesized that CgA is useful for surveillance after NF-PNET resection.

Methods: Comprehensive English literature review by PICO criteria (P-human NF-PNET patients; I-pancreatectomy; C- none; O- CgA correlation with disease recurrence).

Results: Four studies yielded granular data for resected NF-PNET patients. From 333 patients, 113 recurred and 110 (97%) had elevated CgA. Additional 7 studies with mixed gastro-entero-pancreatic NET included 269 NF-PNET patients. In these patients, CgA uniformly predicted disease extent.

Conclusions: Serum Chromogranin A correlates with disease extent in NF-PNET, and is useful for surveillance after resection of NF-PNET.

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
循环嗜铬粒蛋白A与无功能胰腺神经内分泌肿瘤(NF-PNET)患者的疾病程度、进展和复发相关。
目的:无功能胰腺神经内分泌肿瘤(NF-PNET)是一种罕见的具有异质性生物学特征的肿瘤。放射学和血清生物标志物用于切除后监测;然而,没有普遍建立的协议存在。NF-PNET患者血清嗜铬粒蛋白A (CgA)浓度升高,通常与疾病负担相关;许多CgA研究包括胃肠道和胰腺混合人群。我们试图回顾NF-PNET的文献,重点关注切除后的监测,并假设CgA对NF-PNET切除后的监测有用。方法:采用PICO标准(P-human NF-PNET患者;I-pancreatectomy;C -没有;O- CgA与疾病复发的相关性)。结果:四项研究获得了NF-PNET切除患者的详细数据。333例患者中,113例复发,110例(97%)CgA升高。另外7项胃-肠-胰混合NET研究包括269例NF-PNET患者。在这些患者中,CgA一致预测疾病程度。结论:血清嗜铬粒蛋白A与NF-PNET病变程度相关,可用于NF-PNET切除术后的监测。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
Pancreas
Pancreas 医学-胃肠肝病学
CiteScore
4.70
自引率
3.40%
发文量
289
审稿时长
1 months
期刊介绍: Pancreas provides a central forum for communication of original works involving both basic and clinical research on the exocrine and endocrine pancreas and their interrelationships and consequences in disease states. This multidisciplinary, international journal covers the whole spectrum of basic sciences, etiology, prevention, pathophysiology, diagnosis, and surgical and medical management of pancreatic diseases, including cancer.
期刊最新文献
Coupled Plasma Filtration and Adsorption in Eliminating Inflammatory Mediators and Enhancing Sublingual Microcirculation in Severe Acute Pancreatitis. Efficacy of Neoadjuvant Therapy for Resectable Pancreatic Cancer Might be Limited to Biologically Borderline Resectable Cases. Usefulness and Safety of Endoscopic Nasobiliary Drainage for Type 1 Autoimmune Pancreatitis. Enhancing Pancreatic Cancer Therapy With Targeted CD133-Exosome Delivery of PD-L1 siRNA: A Preclinical Investigation. Evaluating Continuous Glucose Monitoring After Total Pancreatectomy With or Without Islet Autotransplantation: A Scoping Systematic Review.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1