Assessment of Various Insulin Resistance Surrogate Indices in Thai People with Type 2 Diabetes Mellitus.

IF 0.6 Q4 ENDOCRINOLOGY & METABOLISM Journal of the ASEAN Federation of Endocrine Societies Pub Date : 2024-01-01 Epub Date: 2024-09-13 DOI:10.15605/jafes.039.02.21

Waralee Chatchomchuan, Yotsapon Thewjitcharoen, Soontaree Nakasatien, Ekgaluck Wanothayaroj, Sirinate Krittiyawong, Thep Himathongkam

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Abstract

Objective: To compare insulin surrogate indices with the homeostasis model assessment of insulin resistance (HOMA-IR) in Thai people with type 2 diabetes (T2D).

Methodology: A cross-sectional study of 97 individuals with T2D was done to determine the association between HOMAIR and seven surrogate indices for insulin resistance. IR was defined as HOMA-IR ≥2.0. The indices included Waist Circumference (WC), Waist-to-Hip Ratio (WHR), Waist-to-Height Ratio (WHtR), Triglyceride-Glucose (TyG) index, estimated Glucose Disposal Rate (eGDR) calculated by WC, BMI, and WHR.

Results: A total of 97 subjects with T2D (36.1% female, mean age 61.7 ± 12.0 years, BMI 26.4 ± 3.7 kg/m², A1C 6.9 ± 1.2%) were studied. The TyG index showed a positive association with HOMA-IR, while eGDR exhibited a negative association. TyG index had the strongest correlation with IR (r = 0.49), while various eGDR formulas showed weaker negative correlations (r = 0.12-0.25). However, subgroup analysis in individuals with T2D and coronary artery disease (CAD) showed that only eGDR-WC and eGDR-BMI demonstrated a significant correlation with triple vessel disease.

Conclusion: The TyG index was a useful and simple marker for identifying the presence of IR in Thai people with T2D. Future longitudinal studies are warranted to demonstrate the prediction value of cardiovascular outcomes.

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泰国2型糖尿病患者各种胰岛素抵抗替代指标的评估

目的：比较胰岛素替代指标与泰国2型糖尿病（T2D）患者胰岛素抵抗（HOMA-IR）的稳态模型评估。方法：对97例T2D患者进行横断面研究，以确定HOMAIR与胰岛素抵抗的7个替代指标之间的关系。IR定义为HOMA-IR≥2.0。指标包括腰围（WC）、腰臀比（WHR）、腰高比（WHtR）、甘油三酯-葡萄糖（TyG）指数、由腰围、BMI和WHR计算的估计葡萄糖处置率（eGDR）。结果：共纳入97例T2D患者，其中女性占36.1%，平均年龄61.7±12.0岁，BMI 26.4±3.7 kg/m2, A1C 6.9±1.2%。TyG指数与HOMA-IR呈正相关，eGDR呈负相关。TyG指数与IR的相关性最强（r = 0.49），而各种eGDR公式的负相关性较弱（r = 0.12 ~ 0.25）。然而，在T2D和冠心病（CAD）患者中进行的亚组分析显示，只有eGDR-WC和eGDR-BMI与三支血管疾病有显著相关性。结论：TyG指数是鉴别泰国T2D患者是否存在IR的有效、简便的指标。未来的纵向研究有必要证明心血管预后的预测价值。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of the ASEAN Federation of Endocrine Societies ENDOCRINOLOGY & METABOLISM-

CiteScore

1.20

自引率

0.00%

发文量

审稿时长

8 weeks

期刊介绍： The Journal of the ASEAN Federation of Endocrine Societies (JAFES) is an OPEN ACCESS, internationally peer-reviewed, English language, medical and health science journal that is published in print two times a year by the ASEAN Federation of Endocrine Societies. It shall serve as the endocrine window between the ASEAN region and the world, featuring original papers and publishing key findings from specialists and experts of endocrinology.