Increased Intracranial Pressure in Myelin-Oligodendrocyte Glycoprotein Antibody-Associated Disease.

IF 1.1 4区医学 Q4 CLINICAL NEUROLOGY Neurologist Pub Date : 2025-01-01 DOI:10.1097/NRL.0000000000000577

Torge Rempe, Aisha Elfasi, Samir Alkabie, Alison Christy, Elsa Rodriguez, Rhaisa Castrodad-Molina, Bryce Buchowicz, Fernando X Cuascut, George Hutton, Revere Kinkel, Jennifer Graves

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Abstract

Objectives: To assess characteristics of increased intracranial pressure (ICP) in myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD).

Methods: This is a multicenter retrospective review of 84 MOGAD cases at the University of Florida, Baylor College of Medicine, the University of California San Diego, and Providence Health and Services, Portland, Oregon, to identify cases with a documented increased opening pressure >25 cm H2O. A literature review was conducted to identify previously reported MOGAD cases with an opening pressure >25 cm H2O.

Results: Of 28 MOGAD cases with available opening pressures, 6 (21.4%) patients (age: 5 to 36 y; 2/6 females) had documented increased ICP with an opening pressure of 26 to 46 cm H2O and optic nerve head edema on funduscopic examination. The increased ICP occurred in the setting of bilateral optic neuritis in all cases. In 5/6 patients, this was the initial presentation of the disorder. Anti-MOG titers were 1:40 (n = 1), 1:100 (n = 4), and 1:1000 (n = 1). In our literature review, we identified 13 additional MOGAD cases with ICP elevations in the setting of meningo-cortical presentations (n = 10), as well as bilateral optic neuritis (n = 3).

Conclusions: Increased ICP may occur in MOGAD and may be more common in patients with optic neuritis or meningoencephalitis.

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髓鞘-少突胶质细胞糖蛋白抗体相关疾病患者颅内压增高。

目的：评价髓鞘少突胶质细胞糖蛋白抗体相关疾病（MOGAD）患者颅内压增高的特点。方法：这是一项对佛罗里达大学、贝勒医学院、加州大学圣地亚哥分校和俄勒冈州波特兰市普罗维登斯健康与服务中心84例MOGAD病例的多中心回顾性研究，以确定有记录的开孔压力增加bbb25 cm H2O的病例。我们进行了一项文献综述，以确定先前报道的开孔压力为bbb25 cm H2O的MOGAD病例。结果：28例MOGAD患者中，6例（21.4%）患者(年龄：5 ~ 36岁；2/6（女性）在眼底检查时发现颅内压升高，开口压为26 ~ 46 cm H2O，视神经头水肿。所有病例的颅内压升高均发生在双侧视神经炎的情况下。在5/6的患者中，这是疾病的初始表现。抗mog滴度分别为1:40 （n = 1）、1:100 （n = 4）和1:100 （n = 1）。在我们的文献综述中，我们发现了另外13例伴有颅内压升高的MOGAD患者（n = 10），以及双侧视神经炎（n = 3）。结论：颅内压升高可能发生在MOGAD患者中，并且可能在视神经炎或脑膜脑炎患者中更为常见。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neurologist 医学-临床神经学

CiteScore

1.90

自引率

0.00%

发文量

151

审稿时长

2 months

期刊介绍： The Neurologist publishes articles on topics of current interest to physicians treating patients with neurological diseases. The core of the journal is review articles focusing on clinically relevant issues. The journal also publishes case reports or case series which review the literature and put observations in perspective, as well as letters to the editor. Special features include the popular "10 Most Commonly Asked Questions" and the "Patient and Family Fact Sheet," a handy tear-out page that can be copied to hand out to patients and their caregivers.