Halil Erbis , Eyyup Mehmet Kilinc , Aynur Camkiran Firat , Cigdem Aliosmanoglu , Mevlut Harun Agca , Ibrahim Aliosmanoglu
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Abstract
Background
Liver transplantation (LT) is a crucial treatment for infants with end-stage liver disease, yet specific data on LT outcomes in infants under 12 months old remain limited. This study aims to present the clinical course and outcomes of infants who underwent LT, assessing the impact of demographic and etiological differences on mortality and survival.
Methods
A retrospective analysis was conducted on 64 infants (< 12 months) who underwent LT between January 2019 and March 2024. Demographic, clinical, and laboratory data were collected from their medical records. LT-specific details, postoperative complications, and survival data were analyzed.
Results
The median age of the infants was 157 days, with 37 boys (57.8%) and 27 girls (42.2%). Biliary atresia was the most common diagnosis (85.9%), and seven infants had undergone a previous Kasai procedure. The median pediatric end-stage liver disease (PELD) score was 15.5. Left lateral segmentectomy was the predominant graft type (60.9%). The median pediatric intensive care unit (PICU) and hospital stays were 5 and 21 days, respectively. Complications occurred in 20 infants (31.3%), with vascular and biliary complication rates both at 12.5%. The overall mortality rate was 17.2%, with early (30-day) and late mortality rates of 6.3% and 10.9%, respectively. The median overall survival (OS) was 204.5 days, and the 1-year survival rate was 32.8%. Kaplan-Meier and log rank analyses showed no significant impact of sex, age, diagnostic groups, graft type, or surgical complications on OS (P > .05).
Conclusions
LT in infants can be performed with acceptable morbidity and mortality rates, particularly with increased experience and standardized protocols.
期刊介绍：
Transplantation Proceedings publishes several different categories of manuscripts, all of which undergo extensive peer review by recognized authorities in the field prior to their acceptance for publication.
The first type of manuscripts consists of sets of papers providing an in-depth expression of the current state of the art in various rapidly developing components of world transplantation biology and medicine. These manuscripts emanate from congresses of the affiliated transplantation societies, from Symposia sponsored by the Societies, as well as special Conferences and Workshops covering related topics.
Transplantation Proceedings also publishes several special sections including publication of Clinical Transplantation Proceedings, being rapid original contributions of preclinical and clinical experiences. These manuscripts undergo review by members of the Editorial Board.
Original basic or clinical science articles, clinical trials and case studies can be submitted to the journal?s open access companion title Transplantation Reports.
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