{"title":"Potential of boron neutron capture therapy (BNCT) for myxofibrosarcoma.","authors":"Takuya Fujimoto, Tooru Andoh, Tamotsu Sudo, Ikuo Fujita, Yoshinori Sakurai, Takushi Takata, Hiroki Tanaka, Teruya Kawamoto, Shunsuke Yahiro, Shotaro Nakamura, Hitomi Hara, Naomasa Fukase, Toshihiro Akisue, Hideki Ichikawa, Ryosuke Kuroda, Minoru Suzuki","doi":"10.1016/j.apradiso.2024.111603","DOIUrl":null,"url":null,"abstract":"<p><p>Myxofibrosarcoma, a rare malignant tumor, predominantly affects the extremities of the elderly. Because of its invasive nature amputation is sometimes required, resulting in serious deterioration of quality of life. Therefore, cell lines established from amputated surgical specimens of myxofibrosarcoma in the upper limbs of elderly patients were used to create a myxofibrosarcoma-bearing animal model and to investigate the therapeutic effect of BNCT thereon. The results demonstrated selective destruction of tumor cells, suggesting the anti-tumor efficacy of BNCT on myxofibrosarcoma.</p>","PeriodicalId":8096,"journal":{"name":"Applied Radiation and Isotopes","volume":"217 ","pages":"111603"},"PeriodicalIF":1.6000,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Applied Radiation and Isotopes","FirstCategoryId":"5","ListUrlMain":"https://doi.org/10.1016/j.apradiso.2024.111603","RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/11/26 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"CHEMISTRY, INORGANIC & NUCLEAR","Score":null,"Total":0}
引用次数: 0
Abstract
Myxofibrosarcoma, a rare malignant tumor, predominantly affects the extremities of the elderly. Because of its invasive nature amputation is sometimes required, resulting in serious deterioration of quality of life. Therefore, cell lines established from amputated surgical specimens of myxofibrosarcoma in the upper limbs of elderly patients were used to create a myxofibrosarcoma-bearing animal model and to investigate the therapeutic effect of BNCT thereon. The results demonstrated selective destruction of tumor cells, suggesting the anti-tumor efficacy of BNCT on myxofibrosarcoma.
期刊介绍：
Applied Radiation and Isotopes provides a high quality medium for the publication of substantial, original and scientific and technological papers on the development and peaceful application of nuclear, radiation and radionuclide techniques in chemistry, physics, biochemistry, biology, medicine, security, engineering and in the earth, planetary and environmental sciences, all including dosimetry. Nuclear techniques are defined in the broadest sense and both experimental and theoretical papers are welcome. They include the development and use of α- and β-particles, X-rays and γ-rays, neutrons and other nuclear particles and radiations from all sources, including radionuclides, synchrotron sources, cyclotrons and reactors and from the natural environment.
The journal aims to publish papers with significance to an international audience, containing substantial novelty and scientific impact. The Editors reserve the rights to reject, with or without external review, papers that do not meet these criteria.
Papers dealing with radiation processing, i.e., where radiation is used to bring about a biological, chemical or physical change in a material, should be directed to our sister journal Radiation Physics and Chemistry.
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