A systematic review of the clinicopathological characteristics of oral leiomyomatous hamartoma.

IF 2.5 3区医学 Q3 ONCOLOGY World Journal of Surgical Oncology Pub Date : 2024-12-05 DOI:10.1186/s12957-024-03607-y

Mario Alberto Alarcón-Sánchez, Mario Nava-Villalba, Lilibeth-Stephania Escoto-Vasquez, Artak Heboyan

{"title":"A systematic review of the clinicopathological characteristics of oral leiomyomatous hamartoma.","authors":"Mario Alberto Alarcón-Sánchez, Mario Nava-Villalba, Lilibeth-Stephania Escoto-Vasquez, Artak Heboyan","doi":"10.1186/s12957-024-03607-y","DOIUrl":null,"url":null,"abstract":"Background: Oral leiomyomatous hamartoma (OLH) corresponds to an abnormal, benign and disorganized overgrowth of mature smooth muscle tissue, which can develop in any site where this tissue is found in healthy conditions. The present systematic review aimed to analyze the clinicopathological characteristics of OLH.Materials and methods: The protocol of this study was constructed following the guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) and was registered in the Open Science Framework (OSF): OSF.IO/BMPUX. Five electronic databases were used to identify studies for this systematic review: PubMed, Web of Science, Dentistry & Oral Science Source, Scopus and ScienceDirect, from January 15th, 1945 to January 10th, 2024. The Joanna Briggs Institute (JBI) tool was used to assess the risk of bias and the quality of the included reports and case series.Results: A comprehensive search yielded 5,562 articles, of which 55 met the inclusion criteria. The total number of subjects studied in the included investigations was sixty-six. The subjects' ages varied from newborns to 61 years, with a mean age ± standard deviation of 71.23 ± 123.01 months. 50.7% were males and 49.3% were females. Most lesions presented normochromic color (24.24%), pedunculated base (31.81%), firm consistency (22.72%), with an average size of 1.20 cm, present on the dorsum of the tongue (31.81%) or anterior part of the alveolar border of the maxilla (30.30%). Treatment was carried out by surgical excision (78.46%) and half of the studies report that there were no recurrences.Conclusions: The cases described in the medical-dental literature provide valuable information to date on the clinicopathologic and immunohistochemical profile of OLH. Although it is a rare lesion, it should be considered as part of the differential diagnosis in newborns, infants, children and young adults with lingual and/or maxillary masses present in the midline.","PeriodicalId":23856,"journal":{"name":"World Journal of Surgical Oncology","volume":"22 1","pages":"326"},"PeriodicalIF":2.5000,"publicationDate":"2024-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11619218/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"World Journal of Surgical Oncology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1186/s12957-024-03607-y","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"ONCOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Background: Oral leiomyomatous hamartoma (OLH) corresponds to an abnormal, benign and disorganized overgrowth of mature smooth muscle tissue, which can develop in any site where this tissue is found in healthy conditions. The present systematic review aimed to analyze the clinicopathological characteristics of OLH.

Materials and methods: The protocol of this study was constructed following the guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) and was registered in the Open Science Framework (OSF): OSF.IO/BMPUX. Five electronic databases were used to identify studies for this systematic review: PubMed, Web of Science, Dentistry & Oral Science Source, Scopus and ScienceDirect, from January 15th, 1945 to January 10th, 2024. The Joanna Briggs Institute (JBI) tool was used to assess the risk of bias and the quality of the included reports and case series.

Results: A comprehensive search yielded 5,562 articles, of which 55 met the inclusion criteria. The total number of subjects studied in the included investigations was sixty-six. The subjects' ages varied from newborns to 61 years, with a mean age ± standard deviation of 71.23 ± 123.01 months. 50.7% were males and 49.3% were females. Most lesions presented normochromic color (24.24%), pedunculated base (31.81%), firm consistency (22.72%), with an average size of 1.20 cm, present on the dorsum of the tongue (31.81%) or anterior part of the alveolar border of the maxilla (30.30%). Treatment was carried out by surgical excision (78.46%) and half of the studies report that there were no recurrences.

Conclusions: The cases described in the medical-dental literature provide valuable information to date on the clinicopathologic and immunohistochemical profile of OLH. Although it is a rare lesion, it should be considered as part of the differential diagnosis in newborns, infants, children and young adults with lingual and/or maxillary masses present in the midline.

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

口腔平滑肌错构瘤临床病理特点的系统综述。

背景：口腔平滑肌错构瘤（OLH）是一种异常的、良性的、无组织的成熟平滑肌组织过度生长，它可以在健康情况下发现的任何部位发展。本系统综述旨在分析OLH的临床病理特征。材料和方法：本研究的方案按照系统评价和荟萃分析首选报告项目（PRISMA）的指导原则构建，并在开放科学框架（OSF）中注册：OSF. io /BMPUX。本系统综述使用了五个电子数据库：PubMed、Web of Science、Dentistry & Oral Science Source、Scopus和ScienceDirect，时间为1945年1月15日至2024年1月10日。使用乔安娜布里格斯研究所（JBI）的工具来评估偏倚风险和纳入的报告和病例系列的质量。结果：综合检索得到5562篇文章，其中55篇符合纳入标准。纳入调查的受试者总数为66人。受试者年龄从新生儿到61岁不等，平均年龄±标准差为71.23±123.01个月。男性50.7%，女性49.3%。多数病变呈正色（24.24%），基部有带梗（31.81%），质地坚硬（22.72%），平均大小1.20 cm，多出现在舌背（31.81%）或上颌骨牙槽缘前部（30.30%）。手术切除治疗（78.46%），半数研究报告无复发。结论：医学-牙科文献中描述的病例提供了有关OLH临床病理和免疫组织化学特征的宝贵信息。虽然这是一种罕见的病变，但在新生儿、婴儿、儿童和年轻成人中出现舌和/或上颌中线肿块时，应将其视为鉴别诊断的一部分。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

World Journal of Surgical Oncology ONCOLOGY-SURGERY

CiteScore

4.70

自引率

15.60%

发文量

362

审稿时长

3 months

期刊介绍： World Journal of Surgical Oncology publishes articles related to surgical oncology and its allied subjects, such as epidemiology, cancer research, biomarkers, prevention, pathology, radiology, cancer treatment, clinical trials, multimodality treatment and molecular biology. Emphasis is placed on original research articles. The journal also publishes significant clinical case reports, as well as balanced and timely reviews on selected topics. Oncology is a multidisciplinary super-speciality of which surgical oncology forms an integral component, especially with solid tumors. Surgical oncologists around the world are involved in research extending from detecting the mechanisms underlying the causation of cancer, to its treatment and prevention. The role of a surgical oncologist extends across the whole continuum of care. With continued developments in diagnosis and treatment, the role of a surgical oncologist is ever-changing. Hence, World Journal of Surgical Oncology aims to keep readers abreast with latest developments that will ultimately influence the work of surgical oncologists.