Impact of Stress on the Endocannabinoid System: A [11C]-CURB Positron Emission Tomography Study in Early Psychosis: Les effets du stress sur le système endocannabinoïde : étude par tomographie par émission de positons avec l'indicateur radioactif [11C-CURB] dans la psychose précoce.
Ana Weidenauer, Ranjini Garani, Paula Campos Oller, Maira Belén Blasco, Pablo M Rusjan, Romina Mizrahi
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引用次数: 0
Abstract
Background: Stress and traumatic experiences are well-established risk factors for psychiatric disorders. Stressful events can induce symptoms of anxiety and depression and may lead to overt psychosis, especially when there is an innate biological vulnerability. This study explores the role of the stress-regulating endocannabinoid system, specifically the activity of the enzyme fatty acid amid hydrolase (FAAH), a key regulatory enzyme for endocannabinoids, in association with stress by analysing data from healthy individuals and patients with psychosis.
Methods: We performed a post-hoc exploratory analysis on 65 positron emission tomography scans using the selective FAAH radioligand [11C]CURB, encompassing 30 patients with psychosis (6 female) and 35 healthy controls (19 female). The study aimed to examine the association between FAAH activity and stressful life events, assessed through the Recent Life Events, Survey of Life Experiences, and Hassles and Uplifts Scale.
Results: There was a significant difference regarding the number of recent stressors with higher levels in patients compared to healthy subjects (Survey of Life Experiences: t = 4.88, p < 0.001, hassles: t = 3.14, p = 0.003), however there was no significant relationship of brain FAAH activity and stressful life events in any of the applied scales across groups (Recent Life Events: F1,57 = 0.07, p = 0.80; Survey of Life Experiences: F1,57 = 1.75, p = 0.19; hassles: F1,56 = 1.06, p = 0.31). Linear mixed models performed separately for each group revealed that there was a positive association between FAAH activity and Recent Life Events in patients with psychosis only (F1,25 = 8.07, p = 0.009).
Conclusions: Our data reveal a significant disparity in recent stressors between the two groups, and a correlation between brain FAAH activity and stressful life events in patients with psychosis only. This suggests a complex interplay between stress and the endocannabinoid system.
Plain language summary title: How Stress Affects the Brain’s Endocannabinoid System in Early Psychosis: A PET Study.
背景：压力和创伤经历是公认的精神疾病的危险因素。压力事件可诱发焦虑和抑郁症状，并可能导致明显的精神病，特别是当存在先天的生物脆弱性时。本研究通过分析健康个体和精神病患者的数据，探讨了应激调节内源性大麻素系统的作用，特别是内源性大麻素的关键调节酶脂肪酸水解酶（FAAH）的活性与应激的关系。方法：我们使用选择性FAAH放射配体[11C]CURB对65个正电子发射断层扫描进行了探索性分析，包括30名精神病患者（6名女性）和35名健康对照（19名女性）。该研究旨在研究FAAH活动与压力生活事件之间的关系，通过近期生活事件、生活经历调查和烦恼与振奋量表进行评估。结果：与健康受试者相比，患者近期应激源水平较高的数量存在显著差异（生活经历调查：t = 4.88, p t = 3.14, p = 0.003），但各组间任何应用量表的脑FAAH活动与应激生活事件均无显著关系(近期生活事件：F1,57 = 0.07, p = 0.80；生活经历调查：F1,57 = 1.75, p = 0.19；麻烦事：F1,56 = 1.06, p = 0.31)。分别对每组进行的线性混合模型显示，仅在精神病患者中，FAAH活性与近期生活事件之间存在正相关（F1,25 = 8.07, p = 0.009）。结论：我们的数据揭示了两组患者近期压力源的显著差异，以及仅在精神病患者中脑FAAH活动与压力生活事件之间的相关性。这表明压力和内源性大麻素系统之间存在复杂的相互作用。
期刊介绍：
Established in 1956, The Canadian Journal of Psychiatry (The CJP) has been keeping psychiatrists up-to-date on the latest research for nearly 60 years. The CJP provides a forum for psychiatry and mental health professionals to share their findings with researchers and clinicians. The CJP includes peer-reviewed scientific articles analyzing ongoing developments in Canadian and international psychiatry.
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