THE GROWING EVIDENCE OF THE RELATIONSHIP BETWEEN OBESITY AND CANCER AND THE ROLE OF BARIATRIC SURGERY.

Arquivos brasileiros de cirurgia digestiva : ABCD = Brazilian archives of digestive surgery Pub Date : 2024-12-02 eCollection Date: 2024-01-01 DOI:10.1590/0102-6720202400044e1838

Paulo Kassab, Álvaro Antônio Bandeira Ferraz, Anna Clara Hebling Mitidieri, Luiz Vicente Berti, Marco Aurélio Santo, Tiago Szego, Caio de Carvalho Zanon, Osvaldo Antônio Prado Castro, Wilson Rodrigues de Freitas Junior, Elias Jirjoss Ilias, Carlos Alberto Malheiros, Antônio Carlos Valez, Antônio Carlos Ligocki Campos

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Abstract

Obesity is recognized as a significant risk factor for various types of cancer. Although the incidence of some types of cancer across various primary sites is decreasing due to specific prevention measures (screening programs, smoking cessation), the incidence of neoplasms in the young population shows a significant increase associated with obesity. There is sufficient evidence to say that bariatric surgery has been shown to significantly lower the risk of developing obesity-associated cancers, which are linked to metabolic dysregulation, chronic low-grade systemic inflammation, and hormonal alterations such as elevated levels of insulin and sex hormones.

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越来越多的证据表明肥胖和癌症之间的关系以及减肥手术的作用。

肥胖被认为是各种癌症的重要风险因素。尽管某些类型的癌症在不同原发部位的发病率由于特定的预防措施（筛查计划，戒烟）正在下降，但年轻人群中肿瘤的发病率显示出与肥胖相关的显著增加。有足够的证据表明，减肥手术已被证明可以显著降低患肥胖相关癌症的风险，而肥胖相关癌症与代谢失调、慢性低度全身性炎症以及胰岛素和性激素水平升高等激素改变有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Arquivos brasileiros de cirurgia digestiva : ABCD = Brazilian archives of digestive surgery

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