The potential of circulating nonesterified fatty acids and sphingolipids in the biological understanding of cognitive decline and dementia.

IF 3.8 3区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Current opinion in lipidology Pub Date : 2025-02-01 Epub Date: 2024-12-06 DOI:10.1097/MOL.0000000000000968

Kristine F Moseholm, Josefine T Meineche, Majken K Jensen

{"title":"The potential of circulating nonesterified fatty acids and sphingolipids in the biological understanding of cognitive decline and dementia.","authors":"Kristine F Moseholm, Josefine T Meineche, Majken K Jensen","doi":"10.1097/MOL.0000000000000968","DOIUrl":null,"url":null,"abstract":"Purpose of review: Cognitive decline and late-onset dementia pose significant challenges in aging societies, and many dementia cases could be prevented or delayed through modification of associated risk factors, many of which are tied to cardiovascular and metabolic dysfunction. As individuals age, the blood-brain barrier becomes more permeable, easing the exchange of molecules between the bloodstream and the brain. Consequently, blood-based biological markers (so-called biomarkers) provide a minimally invasive and accessible means of accessing molecular changes associated with aging and neurodegeneration.Recent findings: Circulating free fatty acids, also called nonesterified fatty acids (NEFAs), and sphingolipids are associated with cardiovascular disease, insulin resistance, and diabetes; thus, could be promising candidates as biomarkers for cognitive decline and dementia.Summary: The opportunity to study such minimally invasive biomarkers further opens up potential new avenues for improved understanding of the underlying biology of diseases of the brain.","PeriodicalId":11109,"journal":{"name":"Current opinion in lipidology","volume":" ","pages":"27-37"},"PeriodicalIF":3.8000,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current opinion in lipidology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1097/MOL.0000000000000968","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/12/6 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Purpose of review: Cognitive decline and late-onset dementia pose significant challenges in aging societies, and many dementia cases could be prevented or delayed through modification of associated risk factors, many of which are tied to cardiovascular and metabolic dysfunction. As individuals age, the blood-brain barrier becomes more permeable, easing the exchange of molecules between the bloodstream and the brain. Consequently, blood-based biological markers (so-called biomarkers) provide a minimally invasive and accessible means of accessing molecular changes associated with aging and neurodegeneration.

Recent findings: Circulating free fatty acids, also called nonesterified fatty acids (NEFAs), and sphingolipids are associated with cardiovascular disease, insulin resistance, and diabetes; thus, could be promising candidates as biomarkers for cognitive decline and dementia.

Summary: The opportunity to study such minimally invasive biomarkers further opens up potential new avenues for improved understanding of the underlying biology of diseases of the brain.

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

循环非酯化脂肪酸和鞘脂在认知能力下降和痴呆的生物学理解中的潜力。

综述目的：认知能力下降和晚发性痴呆是老龄化社会的重大挑战，许多痴呆病例可以通过改变相关危险因素来预防或延迟，其中许多与心血管和代谢功能障碍有关。随着年龄的增长，血脑屏障变得更容易渗透，减缓了血液和大脑之间分子的交换。因此，基于血液的生物标记物（所谓的生物标记物）提供了一种微创和可获得的方法来获取与衰老和神经变性相关的分子变化。最新发现：循环游离脂肪酸，也称为非酯化脂肪酸（NEFAs）和鞘脂与心血管疾病、胰岛素抵抗和糖尿病有关；因此，它可能是认知能力下降和痴呆的有希望的生物标志物。摘要：研究这种微创生物标志物的机会进一步为提高对大脑疾病潜在生物学的理解开辟了潜在的新途径。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Current opinion in lipidology 医学-内分泌学与代谢

CiteScore

6.70

自引率

4.50%

发文量

审稿时长

6-12 weeks

期刊介绍： With its easy-to-digest reviews on important advances in world literature, Current Opinion in Lipidology offers expert evaluation on a wide range of topics from six key disciplines including nutrition and metabolism, genetics and molecular biology, and hyperlipidaemia and cardiovascular disease. Published bimonthly, each issue covers in detail the most pertinent advances in these fields from the previous year. This is supplemented by a section of Bimonthly Updates, which deliver an insight into new developments at the cutting edge of the disciplines covered in the journal.