A comprehensive review of characterization techniques for particle adhesion and powder flowability

Abstract

The study of the flow properties of particles is crucial because it directly impacts the efficiency and product quality of various industrial particulate processes, such as continuous manufacturing of solid oral dosages. However, challenges arise due to the flow behavior of cohesive particles, which tend to adhere to surfaces or other particles, necessitating careful process design. The importance of selecting appropriate measurement pathways for accurate characterization has been overlooked. In response, an overview of measurement technologies for surface energy and cohesive/adhesive forces is provided in this work, aiming to establish a practical guide. Understanding these forces is crucial for optimizing continuous manufacturing processes to effectively mitigate flow-related issues such as obstructions, segregation, irregular flow, and flooding. Furthermore, various methods characterization experiments were conducted and compared to illuminate the methodological disparities. This analysis provides valuable insights into particle adhesion, cohesion, and powder flowability, potentially enhancing industrial particulate processes development.