Rewiring of the glymphatic landscape in metabolic disorders.

IF 11.4 1区医学 Q1 ENDOCRINOLOGY & METABOLISM Trends in Endocrinology and Metabolism Pub Date : 2024-12-04 DOI:10.1016/j.tem.2024.11.005

Bandy Chen, David Meseguer, Stephanie Lenck, Jean-Leon Thomas, Marc Schneeberger

引用次数: 0

Abstract

The incorporation of the glymphatic clearance system in the study of brain physiology aids in the advancement of innovative diagnostic and treatment strategies for neurological disorders. Exploring the glymphatic system across (from) neurological and (to) metabolic diseases may provide a better link between obesity and neurological disorders. Recent studies indicate the role of metabolic dysfunction as a risk factor for cognitive decline and neurological disorders through the disruption of the glymphatic system. Further investigation into how metabolic dysfunction disrupts glymphatic homeostasis and the domino effects on the neurovascular landscape, including neurovascular uncoupling, cerebral blood flow disruptions, blood-brain barrier leakage, and demyelination, can provide mechanistic insights into the link between obesity and neurological disorders.

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代谢紊乱中淋巴系统景观的重新布线。

脑生理学研究中淋巴清除系统的结合有助于神经系统疾病的创新诊断和治疗策略的发展。探索横跨神经系统和代谢性疾病的淋巴系统可能为肥胖和神经系统疾病之间提供更好的联系。最近的研究表明，代谢功能障碍通过破坏淋巴系统作为认知能力下降和神经系统疾病的危险因素。进一步研究代谢功能障碍如何破坏淋巴稳态和神经血管景观的多米诺骨牌效应，包括神经血管解耦、脑血流中断、血脑屏障泄漏和脱髓鞘，可以为肥胖和神经疾病之间的联系提供机制见解。

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来源期刊

Trends in Endocrinology and Metabolism 医学-内分泌学与代谢

CiteScore

20.10

自引率

0.00%

发文量

审稿时长

82 days

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