Development of a Topical Curcumin Gel for Skin Burn Regeneration.

Abstract

Topical treatment of burn wounds in all stages of burns plays an important role in the course and outcome of the acute period of burn injury, the patient's recovery time, and the development of infectious complications. Curcumin is considered a promising raw material in dermatology practice due to its accelerated wound-healing properties. However, as a result of the studies, it became clear that curcumin-based topical gel drug form for the treatment of burns has not been developed. In this study, we developed a new composition of the gel form for the treatment of burn wounds and its qualitative parameters were identified by Raman spectroscopy. A series of curcumin-containing gel formulations were prepared and evaluated based on their consistency, homogeneity, stability, and curcumin concentration, with the objective of identifying the optimal formulation. Drug kinetics were studied using diffusion methods. It has been demonstrated that a stable and pharmacologically active gel containing curcumin can be created, which has the potential for use in the clinical treatment of burn wounds.