{"title":"Clinical Features and Prognosis of Malignant Cutaneous Adnexal Tumors: A Retrospective Study Using a Japanese Database.","authors":"Shogo Wada, Taisuke Ishii, Dai Ogata, Eiji Nakano, Kenjiro Namikawa, Naoya Yamazaki, Takahiro Higashi","doi":"10.1002/jso.28012","DOIUrl":null,"url":null,"abstract":"<p><p>Malignant cutaneous adnexal tumors (MCATs) are rare. Previous population-based studies to determine the clinical features and prognosis of MCATs mainly included Caucasian patients, and the characteristics of Asian patients with MCATs have not yet been investigated. We aimed to investigate the characteristics of Asian patients with MCAT using a Japanese database. This retrospective study of patients with MCATs from 2012 to 2015 was conducted using a database linked to the Hospital-Based Cancer Registry and Diagnosis Procedure Combination data. Patient characteristics and survival data were analyzed using the Kaplan-Meier method and Cox regression analysis. A total of 1930 patients were included. The median age at diagnosis was 76 years (range, 14-107 years), and 46.3% of the patients were male. The most common histological finding was sebaceous adenocarcinoma (41.6%), followed by porocarcinoma (21.7%). The 5-year overall survival rate was 72.3% (95% confidence interval [CI]: 70.2%-74.3%). A favorable factor for overall survival was female sex (hazard ratio [HR]: 0.78, 95% CI: 0.64-0.96), while unfavorable factors were age > 80 years (HR: 4.40, 95% CI: 3.56-5.46), Stage ≥II (Stage II, HR: 1.34, 95% CI: 1.05-1.71; Stage III, HR: 3.12, 95% CI: 2.16-4.50; Stage IV, HR: 7.31, 95% CI: 4.92-10.87), and histologic findings of spiradenocarcinoma (HR: 4.66, 95% CI: 1.64-13.24). Tumor characteristics and prognosis of MCATs differed among subtypes. Moreover, we found differences between our data and those from other databases. Further investigations are warranted to explore these differences.</p>","PeriodicalId":17111,"journal":{"name":"Journal of Surgical Oncology","volume":" ","pages":""},"PeriodicalIF":2.0000,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Surgical Oncology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1002/jso.28012","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"ONCOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Malignant cutaneous adnexal tumors (MCATs) are rare. Previous population-based studies to determine the clinical features and prognosis of MCATs mainly included Caucasian patients, and the characteristics of Asian patients with MCATs have not yet been investigated. We aimed to investigate the characteristics of Asian patients with MCAT using a Japanese database. This retrospective study of patients with MCATs from 2012 to 2015 was conducted using a database linked to the Hospital-Based Cancer Registry and Diagnosis Procedure Combination data. Patient characteristics and survival data were analyzed using the Kaplan-Meier method and Cox regression analysis. A total of 1930 patients were included. The median age at diagnosis was 76 years (range, 14-107 years), and 46.3% of the patients were male. The most common histological finding was sebaceous adenocarcinoma (41.6%), followed by porocarcinoma (21.7%). The 5-year overall survival rate was 72.3% (95% confidence interval [CI]: 70.2%-74.3%). A favorable factor for overall survival was female sex (hazard ratio [HR]: 0.78, 95% CI: 0.64-0.96), while unfavorable factors were age > 80 years (HR: 4.40, 95% CI: 3.56-5.46), Stage ≥II (Stage II, HR: 1.34, 95% CI: 1.05-1.71; Stage III, HR: 3.12, 95% CI: 2.16-4.50; Stage IV, HR: 7.31, 95% CI: 4.92-10.87), and histologic findings of spiradenocarcinoma (HR: 4.66, 95% CI: 1.64-13.24). Tumor characteristics and prognosis of MCATs differed among subtypes. Moreover, we found differences between our data and those from other databases. Further investigations are warranted to explore these differences.
期刊介绍:
The Journal of Surgical Oncology offers peer-reviewed, original papers in the field of surgical oncology and broadly related surgical sciences, including reports on experimental and laboratory studies. As an international journal, the editors encourage participation from leading surgeons around the world. The JSO is the representative journal for the World Federation of Surgical Oncology Societies. Publishing 16 issues in 2 volumes each year, the journal accepts Research Articles, in-depth Reviews of timely interest, Letters to the Editor, and invited Editorials. Guest Editors from the JSO Editorial Board oversee multiple special Seminars issues each year. These Seminars include multifaceted Reviews on a particular topic or current issue in surgical oncology, which are invited from experts in the field.