Cannabis use in youth is associated with chronic inflammation.

IF 5.9 2区 医学 Q1 PSYCHIATRY Psychological Medicine Pub Date : 2024-12-09 DOI:10.1017/S0033291724002848
Emmet Power, David Mongan, Colm Healy, Subash Raj Susai, Melanie Föcking, Stanley Zammit, Mary Cannon, David Cotter
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Abstract

Background: Markers of inflammation and cannabis exposure are associated with an increased risk of mental disorders. In the current study, we investigated associations between cannabis use and biomarkers of inflammation.

Methods: Utilizing a sample of 914 participants from the Avon Longitudinal Study of Parents and Children, we investigated whether interleukin-6 (IL-6), tumor necrosis factor α (TNFα), C-reactive protein (CRP), and soluble urokinase plasminogen activator receptor (suPAR) measured at age 24 were associated with past year daily cannabis use, less frequent cannabis use, and no past year cannabis use. We adjusted for a number of covariates including sociodemographic measures, body mass index, childhood trauma, and tobacco smoking. We found evidence of a strong association between daily or near daily cannabis use and suPAR.

Results: We did not find any associations between less frequent cannabis use and suPAR. We did not find evidence of an association between IL-6, TNFα or CRP, and cannabis use.

Conclusions: Our finding that frequent cannabis use is strongly associated with suPAR, a biomarker of systemic chronic inflammation implicated in neurodevelopmental and neurodegenerative processes is novel. These findings may provide valuable insights into biological mechanisms by which cannabis affects the brain and impacts the risk of serious mental disorders.

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背景:炎症标志物和大麻暴露与精神障碍风险增加有关。在本研究中,我们调查了使用大麻与炎症生物标志物之间的关系:我们利用雅芳父母与子女纵向研究(Avon Longitudinal Study of Parents and Children)的 914 名参与者样本,调查了 24 岁时测量的白细胞介素-6(IL-6)、肿瘤坏死因子α(TNFα)、C 反应蛋白(CRP)和可溶性尿激酶纤溶酶原激活剂受体(suPAR)是否与过去一年每天使用大麻、较少使用大麻和过去一年未使用大麻有关。我们对一些协变量进行了调整,包括社会人口学测量、体重指数、童年创伤和吸烟。我们发现有证据表明,每天或接近每天吸食大麻与 suPAR 之间存在密切联系:我们没有发现使用大麻频率较低与 suPAR 之间存在任何关联。我们没有发现 IL-6、TNFα 或 CRP 与吸食大麻有关的证据:我们发现,频繁吸食大麻与 suPAR(一种全身慢性炎症的生物标志物,与神经发育和神经退行性过程有关)密切相关,这是一项新发现。这些发现可能为了解大麻影响大脑和影响严重精神障碍风险的生物机制提供了有价值的见解。
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来源期刊
Psychological Medicine
Psychological Medicine 医学-精神病学
CiteScore
11.30
自引率
4.30%
发文量
711
审稿时长
3-6 weeks
期刊介绍: Now in its fifth decade of publication, Psychological Medicine is a leading international journal in the fields of psychiatry, related aspects of psychology and basic sciences. From 2014, there are 16 issues a year, each featuring original articles reporting key research being undertaken worldwide, together with shorter editorials by distinguished scholars and an important book review section. The journal''s success is clearly demonstrated by a consistently high impact factor.
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