S-Aryl(tetramethyl)isothiouronium salts as possible antimicrobial agents--III.

Il Farmaco; edizione scientifica Pub Date : 1988-12-01
A Tait, M G Giovannini, M Di Bella, M Bondi, G P Quaglio
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Abstract

A series of S-Aryl(tetramethyl)isothiouronium salts were prepared and evaluated in vitro for antimicrobial activity. Some compounds revealed interesting inhibiting action on Gram-positive bacteria which is noteworthy in view of the large number of strains antagonized and of the low MIC values. The possible influence of decomposition kinetics to the corresponding mercaptoderivatives was intestigated and compared with those of salts previously studied.

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s-芳基(四甲基)异硫脲盐作为可能的抗菌剂——III。
制备了一系列s -芳基(四甲基)异硫脲盐,并对其体外抑菌活性进行了评价。一些化合物对革兰氏阳性菌显示出有趣的抑制作用,考虑到拮抗菌株数量多且MIC值低,值得注意。研究了分解动力学对相应巯基衍生物的可能影响,并与先前研究的盐类进行了比较。
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Synthesis, binding affinities for alpha-adrenoceptor and eudismic analysis of chiral benzodioxane derivatives and their chiral opened analogues. Prolyl derivatives of enalapril as potential angiotensin converting enzyme inhibitors. Synthesis, structure and activity of a few open models related to classic H2-antagonists. Benzodioxanes and quinazolines: probes for characterizing alpha-adrenoreceptors. Isolation and structure determination of the main related substances of teicoplanin, a glycopeptide antibiotic.
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