E. V. Ambul, N. D. Goletskiy, A. A. Naumov, E. A. Puzikov, M. V. Mamchich, E. O. Zagladkin, N. A. Dedov, N. A. Semenova, S. A. Rodionov, N. V. Kovalev, A. M. Prokoshin, I. A. Ushakov, V. V. Zukau
{"title":"Flowsheet Testing for Separation of Lutetium-177 from an Irradiated Ytterbium Target","authors":"E. V. Ambul, N. D. Goletskiy, A. A. Naumov, E. A. Puzikov, M. V. Mamchich, E. O. Zagladkin, N. A. Dedov, N. A. Semenova, S. A. Rodionov, N. V. Kovalev, A. M. Prokoshin, I. A. Ushakov, V. V. Zukau","doi":"10.1134/S1066362224050047","DOIUrl":null,"url":null,"abstract":"<p>The results of an experiment to verify a complex technology for isolation of <sup>177</sup>Lu from an irradiated 1-g ytterbium target are presented. The main components of the experimental installation, which is mounted in a research hot cell, are described. These components include the extraction and separation of lutetium and ytterbium, the evaporation and preconcentration of <sup>177</sup>Lu, and its chromatographic purification. The feasibility of obtaining a pharmaceutical substance no carrier added lutetium-177 trichloride that meets the standards set by the European Pharmacopoeia has been confirmed.</p>","PeriodicalId":747,"journal":{"name":"Radiochemistry","volume":"66 5","pages":"689 - 701"},"PeriodicalIF":0.9000,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Radiochemistry","FirstCategoryId":"1085","ListUrlMain":"https://link.springer.com/article/10.1134/S1066362224050047","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CHEMISTRY, INORGANIC & NUCLEAR","Score":null,"Total":0}
引用次数: 0
Abstract
The results of an experiment to verify a complex technology for isolation of 177Lu from an irradiated 1-g ytterbium target are presented. The main components of the experimental installation, which is mounted in a research hot cell, are described. These components include the extraction and separation of lutetium and ytterbium, the evaporation and preconcentration of 177Lu, and its chromatographic purification. The feasibility of obtaining a pharmaceutical substance no carrier added lutetium-177 trichloride that meets the standards set by the European Pharmacopoeia has been confirmed.
期刊介绍：
Radiochemistry is a journal that covers the theoretical and applied aspects of radiochemistry, including basic nuclear physical properties of radionuclides; chemistry of radioactive elements and their compounds; the occurrence and behavior of natural and artificial radionuclides in the environment; nuclear fuel cycle; radiochemical analysis methods and devices; production and isolation of radionuclides, synthesis of labeled compounds, new applications of radioactive tracers; radiochemical aspects of nuclear medicine; radiation chemistry and after-effects of nuclear transformations.
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