The Potential Role of Neutrophil Reactivity Intensity and Reactive Lymphocytes as Extended Hematological Parameters to Detect Active Systemic Lupus Erythematosus

IF 2.4 4区医学 Q2 RHEUMATOLOGY International Journal of Rheumatic Diseases Pub Date : 2024-12-10 DOI:10.1111/1756-185X.15449

Andri Iskandar Mardia, Laniyati Hamijoyo, Evan Susandi, Delita Prihatni, Bachti Alisjahbana, Amaylia Oehadian

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Abstract

Objectives

Systemic Lupus Erythematosus (SLE) is a chronic autoimmune disease characterized by the presence of autoantibodies against nuclear antigens and immune complex deposition. The pathogenesis of SLE is not fully understood; however, there are alterations in neutrophils and lymphocytes. Recent parameters assessing both neutrophil activations (Neut-RI, Neut-GI, IG) and activated lymphocytes (Re-Lymp, As-Lymp) can be used to assess the activation of immune cells. The aim of this study was to explore the potential role of this parameter in detecting active SLE.

Methods

Cross-sectional study using secondary data from Hasan Sadikin Lupus Registry. Parameters were examined using Sysmex XN-1500. Lupus activity was determined according to SLEDAI-2K.

Results

This study included 30 active (SLEDAI 2K ≥ 4) and 30 inactive SLE patients. Compared to inactive SLE, active SLE showed significantly higher Neut-RI (51.5 vs. 49.6 FL, p = 0.004), and lower Re-Lymph (0.09 vs. 0.14 × 10³/mm³, p = 0.024). There was no significant difference in Neut-GI (150 vs. 151.6 SI, p = 0.359), As-Lymp (0.02 vs. 0.01 × 10³/mm³, p = 0.621), and IG (0.11 vs. 0.06 × 10³/mm³, p = 0.384) between active and inactive SLE. Neut-RI/Re-Lymp ratio cutoff > 0.47 could distinguish between active and inactive SLE with AUC 0.689, 66.7% sensitivity, and 70.0% specificity.

Conclusion

In active SLE, there is an elevation in Neut-RI and a reduction in Re-Lymp. Neut-RI/Re-Lymp ratio exceeding 0.47 could be used to detect active SLE.

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中性粒细胞反应性强度和反应性淋巴细胞作为扩展血液学参数检测活动性系统性红斑狼疮的潜在作用。

目的：系统性红斑狼疮（SLE）是一种慢性自身免疫性疾病，其特征是存在针对核抗原的自身抗体和免疫复合物沉积。SLE的发病机制尚不完全清楚；然而，中性粒细胞和淋巴细胞有改变。评估中性粒细胞活化（Neut-RI, Neut-GI， IG）和活化淋巴细胞（Re-Lymp, As-Lymp）的最新参数可用于评估免疫细胞的活化。本研究的目的是探讨该参数在检测活动性SLE中的潜在作用。方法：采用Hasan Sadikin狼疮登记处的二手资料进行横断面研究。使用Sysmex XN-1500检测参数。根据SLEDAI-2K测定狼疮活动度。结果：本研究纳入30例活动性（SLEDAI 2K≥4）和30例非活动性SLE患者。与非活动性SLE相比，活动性SLE的Neut-RI明显升高（51.5比49.6 FL, p = 0.004）， Re-Lymph明显降低（0.09比0.14 × 103/mm3, p = 0.024）。活动性和非活动性SLE的net - gi （150 vs. 151.6 SI, p = 0.359）、As-Lymp （0.02 vs. 0.01 × 103/mm3, p = 0.621）和IG （0.11 vs. 0.06 × 103/mm3, p = 0.384）无显著差异。Neut-RI/Re-Lymp比值截断值> 0.47可区分活动性和非活动性SLE， AUC为0.689，敏感性为66.7%，特异性为70.0%。结论：在活动性SLE中，Neut-RI升高，Re-Lymp降低。Neut-RI/Re-Lymp比值大于0.47可用于SLE活动性检测。

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来源期刊

International Journal of Rheumatic Diseases RHEUMATOLOGY-

CiteScore

3.70

自引率

4.00%

发文量

362

审稿时长

1 months

期刊介绍： The International Journal of Rheumatic Diseases (formerly APLAR Journal of Rheumatology) is the official journal of the Asia Pacific League of Associations for Rheumatology. The Journal accepts original articles on clinical or experimental research pertinent to the rheumatic diseases, work on connective tissue diseases and other immune and allergic disorders. The acceptance criteria for all papers are the quality and originality of the research and its significance to our readership. Except where otherwise stated, manuscripts are peer reviewed by two anonymous reviewers and the Editor.