Reporting Bone Cytopathology—A Proposal Based on a Single Tertiary Centre Experience

IF 1.2 4区医学 Q4 CELL BIOLOGY Cytopathology Pub Date : 2024-12-09 DOI:10.1111/cyt.13462

Jan Köster, Camila Bedeschi Rego De Mattos, Henryk A. Domanski

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Abstract

Objective

Fine-needle aspiration cytology (FNAC) from bone lesions has been proven to be a useful diagnostic tool but lacks standardisation. The aim of the study was to evaluate the diagnostic utility of FNAC as a basis to propose and test a reporting system for bone reporting cytopathology.

Methods

This retrospective study is based on patients with bone lesions, that were approached by cytology at Skåne University Hospital, Sweden between 2015 and 2023. The diagnostic performance was measured by sensitivity, specificity and accuracy analyses. All diagnoses were then distributed in six categories: (I) Non-diagnostic, (II) Benign, (III) Atypia, (IV) Bone neoplasm of uncertain significance, (V) Suspicious for malignancy and (VI) Malignant. The risk of malignancy (ROM) in each category was calculated.

Results

The final cohort consisted of 721 cases. Bone cytology was able to differentiate between benign and malignant lesion with a sensitivity of 89% and a specificity of 99%. The overall diagnostic accuracy was 65% but varied significantly among different types of lesions. Within the tested diagnostic categories, the ROM was (I) 48%, (II) 6.7%, (III) 69%, (IV) 28%, (V) 93% and (VI) 100%.

Conclusion

FNAC from bone lesions is a sensitive and specific diagnostic tool with high diagnostic accuracy among various tumour types. This study provides valuable insights for the development of a standardised reporting system for bone cytopathology.

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报告骨细胞病理学-基于单一三级中心经验的建议。

目的：骨病变细针穿刺细胞学（FNAC）已被证明是一种有用的诊断工具，但缺乏标准化。本研究的目的是评估FNAC的诊断效用，作为提出和测试骨细胞病理学报告系统的基础。方法：本回顾性研究基于2015年至2023年间在瑞典sk大学医院接受细胞学检查的骨病变患者。通过敏感性、特异性和准确性分析来衡量诊断效果。然后将所有诊断分为六类：(I)非诊断性，（II）良性，（III）异型性，（IV）意义不确定的骨肿瘤，(V)可疑恶性和（VI）恶性。计算每个类别的恶性肿瘤风险（ROM）。结果：最终队列包括721例。骨细胞学能够区分良性和恶性病变，敏感性为89%，特异性为99%。总体诊断准确率为65%，但不同类型病变之间差异显著。在测试的诊断类别中，ROM为(I) 48%, (II) 6.7%, (III) 69%, (IV) 28%, (V) 93%, (VI) 100%。结论：骨病变FNAC是一种敏感、特异的诊断工具，对不同类型肿瘤具有较高的诊断准确率。本研究为骨细胞病理学标准化报告系统的发展提供了有价值的见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cytopathology 生物-病理学

CiteScore

2.30

自引率

15.40%

发文量

107

审稿时长

6-12 weeks

期刊介绍： The aim of Cytopathology is to publish articles relating to those aspects of cytology which will increase our knowledge and understanding of the aetiology, diagnosis and management of human disease. It contains original articles and critical reviews on all aspects of clinical cytology in its broadest sense, including: gynaecological and non-gynaecological cytology; fine needle aspiration and screening strategy. Cytopathology welcomes papers and articles on: ultrastructural, histochemical and immunocytochemical studies of the cell; quantitative cytology and DNA hybridization as applied to cytological material.