Angiotensin II administration in severe thrombocytopenia and chronic venous thrombosis: A case report.

Ana Vujaklija Brajkovic, Andrej Markota, Luka Bielen, Andro Vujević, Mia Rora, Radovan Radonic
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Abstract

Background: The initial trials on angiotensin II (AT II) administration indicated a high incidence of thrombocytopenia and thrombosis, as well as a positive correlation between hyperreninemia and response to the medication.

Case summary: We describe a case of a patient presenting with catecholamine resistant septic shock, thrombocytopenia, deep vein thrombosis, and normal renin concentration who responded immediately to AT II treatment. We observed no worsening of thrombocytopenia and no progression of thrombosis or additional thromboses during treatment.

Conclusion: Our case underscores the need for individualized assessment of patients for potential therapy with AT II.

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血管紧张素II在严重血小板减少症和慢性静脉血栓中的应用:1例报告。
背景:血管紧张素II (AT II)给药的初步试验表明,血小板减少和血栓形成的发生率高,高肾素血症与药物反应呈正相关。病例总结:我们描述了一个病例,患者表现为儿茶酚胺耐药感染性休克,血小板减少,深静脉血栓形成,肾素浓度正常,立即响应AT II治疗。在治疗期间,我们没有观察到血小板减少症的恶化和血栓形成的进展或额外的血栓形成。结论:我们的病例强调了对AT II潜在治疗的患者进行个体化评估的必要性。
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