{"title":"Diagnosis of ccRCC","authors":"Isobel Leake","doi":"10.1038/s41585-024-00988-3","DOIUrl":null,"url":null,"abstract":"<p>Diagnosis of clear cell renal cell carcinoma (ccRCC) is challenging, particularly as [<sup>18</sup>F]FDG PET–CT is not routinely recommended. Novel single-domain antibody (sdAb) tracers could be useful in cancer imaging owing to their small size and high target recognition.</p><p>In the first part of a study published in the <i>Journal of Nuclear Medicine</i>, Zhou et al. analysed CD70 expression in RCC and normal kidney tissues, given its known potential as a diagnostic and therapeutic target. Normal kidney tissue did not express CD70, and CD70 expression was significantly higher in ccRCC than in papillary RCC (<i>P</i> < 0.001) and chromophobe RCC (<i>P</i> < 0.001). Notably, CD70 expression was unaffected by tumour differentiation or metastasis status.</p>","PeriodicalId":19088,"journal":{"name":"Nature Reviews Urology","volume":"96 1","pages":""},"PeriodicalIF":12.1000,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature Reviews Urology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1038/s41585-024-00988-3","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"UROLOGY & NEPHROLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Diagnosis of clear cell renal cell carcinoma (ccRCC) is challenging, particularly as [18F]FDG PET–CT is not routinely recommended. Novel single-domain antibody (sdAb) tracers could be useful in cancer imaging owing to their small size and high target recognition.
In the first part of a study published in the Journal of Nuclear Medicine, Zhou et al. analysed CD70 expression in RCC and normal kidney tissues, given its known potential as a diagnostic and therapeutic target. Normal kidney tissue did not express CD70, and CD70 expression was significantly higher in ccRCC than in papillary RCC (P < 0.001) and chromophobe RCC (P < 0.001). Notably, CD70 expression was unaffected by tumour differentiation or metastasis status.
期刊介绍：
Nature Reviews Urology is part of the Nature Reviews portfolio of journals.Nature Reviews' basic, translational and clinical content is written by internationally renowned basic and clinical academics and researchers. This journal targeted readers in the biological and medical sciences, from the postgraduate level upwards, aiming to be accessible to professionals in any biological or medical discipline.
The journal features authoritative In-depth Reviews providing up-to-date information on topics within a field's history and development. Perspectives, News & Views articles, and the Research Highlights section offer topical discussions and opinions, filtering primary research from various medical journals.
Covering a wide range of subjects, including andrology, urologic oncology, and imaging, Nature Reviews provides valuable insights for practitioners, researchers, and academics within urology and related fields.
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