Blood coagulation and fibrinolysis after confinement hypokinesia.

Abstract

Our previous studies dealt with the dynamics of the fluid-coagulant equilibrium in rats after confinement hypokinesia (CHK) for 1, 2 and 3 weeks obtained by placing them in small cages permitting only slight movements for spontaneous feeding. We found an acceleration of blood coagulation and fibrinolysis, with a maximal response after 1-2 weeks. In this work attention focussed on the initial more dynamic interval of 1, 3 and 7 days of exposure to CHK. To find certain relations between the central vegetative stimuli and the peripheral responses, experiments were done on normal and adrenalectomized rats and plasma corticosterone, the main glucocorticoid in these species, was measured. CHK accelerated the Quick and the Howell time (QT and HT) and euglobulin lysis time (ELT) progressively, beginning with the first day of exposure. Adrenalectomy as such shortened these parameters, demonstrating an inhibitory action of corticoid hormones in normal conditions. Exposure to CHK of adrenalectomised rats emphasizes these inhibitions. We did not found evident correlations between plasma corticosterone and these processes. The number of thrombocytes had a similar evolution, but in adrenalectomised and CHK rats they increase.