Staging Chronic Hepatitis B Related Liver Fibrosis with Diffusion-weighted MRI-based Virtual Elastography: Comparisons with Serum Fibrosis Indexes.

IF 2.1 3区医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Clinical radiology Pub Date : 2025-01-01 Epub Date: 2024-11-16 DOI:10.1016/j.crad.2024.106750

L Yang, G Zhou, L Liu, S Rao, W Wang, K Jin, F Wu, C Fu, M Zeng, Y Ding

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Abstract

Aim: To evaluate and compare the diagnostic performance of diffusion-weighted imaging (DWI)-based virtual magnetic resonance (MR) elastography and serum fibrosis indexes for staging liver fibrosis in patients with chronic hepatitis B (CHB).

Materials and methods: This retrospective study included 145 patients with CHB. Virtual shear modulus (μ_Diff) was derived from DWI acquisition with b values of 200 and 1500/mm². Aspartate aminotransferase to platelet ratio index (APRI), fibrosis-4 index (FIB-4), S index, Fibro Q and gamma-glutamyl transpeptidase to platelet ratio (GPR) were calculated. The diagnostic efficacies of μ_Diff and serum indexes for staging liver fibrosis were compared.

Results: μ_Diff, APRI, FIB-4, S index, Fibro Q, and GPR increased as the hepatic fibrosis progressed (r=0.23-0.52, P<0.05). Areas under the curves (AUCs) of μ_Diff were 0.725, 0.817 and 0.764 for significant fibrosis, advanced fibrosis, and cirrhosis, respectively. μ_Diff had greater AUC over FIB-4 (0.686) and Fibro Q (0.638) for advanced fibrosis (P<0.05). The AUCs of combination of μ_Diff with APRI, FIB-4, S index, Fibro Q, and GPR individually were 0.779, 0.772, 0.763, 0.728, and 0.756 for significant fibrosis, 0.856, 0.842, 0.834, 0.831, and 0.834 for advanced fibrosis, 0.811, 0.818, 0.784, 0.835, and 0.788 for cirrhosis, respectively. The AUCs of the combinations were significantly higher than individual serum index for advanced fibrosis and cirrhosis (all P<0.05).

Conclusion: DWI-based virtual MR elastography could estimate liver fibrosis stages in patients with CHB, which outperformed FIB-4 and Fibro Q for advanced fibrosis. The combination of μ_Diff with each serum index appears superior to individual serum index for advanced fibrosis and cirrhosis.

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基于弥散加权mri虚拟弹性成像的慢性乙型肝炎相关肝纤维化分期：与血清纤维化指标的比较。

目的：评价和比较基于弥散加权成像（DWI）的虚拟磁共振（MR）弹性成像和血清纤维化指标对慢性乙型肝炎（CHB）患者肝纤维化分期的诊断价值。材料与方法：本研究纳入145例慢性乙型肝炎患者。虚拟剪切模量（μDiff）由DWI采集得到，b值分别为200和1500/mm2。计算天冬氨酸转氨酶血小板比值指数（APRI）、纤维化-4指数（FIB-4）、S指数、Fibro Q和γ -谷氨酰转肽酶血小板比值（GPR）。比较μDiff和血清指标对肝纤维化分期的诊断效果。结果：随着肝纤维化进展，μDiff、APRI、FIB-4、S指数、Fibro Q、GPR均升高（r=0.23 ~ 0.52），显著纤维化、晚期纤维化、肝硬化的PDiff分别为0.725、0.817、0.764。对于晚期纤维化，μDiff的AUC高于FIB-4（0.686）和Fibro Q (0.638) (PDiff与APRI、FIB-4、S指数、Fibro Q和GPR分别为0.779、0.772、0.763、0.728和0.756，对于晚期纤维化，PDiff分别为0.856、0.842、0.834、0.831和0.834，对于肝硬化，PDiff分别为0.811、0.818、0.784、0.835和0.788。结论：基于dwi的虚拟MR弹性成像可以估计CHB患者的肝纤维化分期，优于FIB-4和Fibro Q对晚期纤维化的诊断。对于晚期纤维化和肝硬化，μDiff与各血清指标联合应用优于单项血清指标。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical radiology 医学-核医学

CiteScore

4.70

自引率

3.80%

发文量

528

审稿时长

76 days

期刊介绍： Clinical Radiology is published by Elsevier on behalf of The Royal College of Radiologists. Clinical Radiology is an International Journal bringing you original research, editorials and review articles on all aspects of diagnostic imaging, including: • Computed tomography • Magnetic resonance imaging • Ultrasonography • Digital radiology • Interventional radiology • Radiography • Nuclear medicine Papers on radiological protection, quality assurance, audit in radiology and matters relating to radiological training and education are also included. In addition, each issue contains correspondence, book reviews and notices of forthcoming events.